| Unsuspected caffeine toxicity complicating theophylline therapy. | |
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MedLine Citation:
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PMID: 6526399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 58-year-old man with a history of alcoholic liver disease and chronic airflow obstruction presented with heart failure and acute bronchitis. Plasma methylxanthines were estimated as a guide to further theophylline therapy and serious caffeine accumulation was noted in the presence of a subtherapeutic concentration of theophylline. After 3 weeks on a caffeine-free diet theophylline and caffeine challenge tests were performed which demonstrated the ease with which caffeine could accumulate. The importance of caffeine accumulation during theophylline therapy is discussed. |
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Authors:
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S A Iversen; P G Murphy; T E Leakey; A Rydlewski; R D Levy; D Gertner |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Human toxicology Volume: 3 ISSN: 0144-5952 ISO Abbreviation: Hum Toxicol Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-03-25 Completed Date: 1985-03-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8206759 Medline TA: Hum Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 509-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bronchitis
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drug therapy Caffeine / blood, poisoning* Half-Life Humans Liver Diseases, Alcoholic / complications Male Middle Aged Theophylline / blood, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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58-08-2/Caffeine; 58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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