Document Detail

Unsuspected acetaminophen toxicity in a 58-day-old infant.
MedLine Citation:
PMID:  15572971     Owner:  NLM     Status:  MEDLINE    
Acetaminophen is frequently used by both physicians and parents for the relief of pain and fever in infants and children of all age groups. It has an excellent safety profile in therapeutic doses, but hepatotoxicity can develop following both intentional or unintentional overdoses. Repetitive doses of acetaminophen, usually in supratherapeutic amounts, but not always, in ill infants have been associated with hepatotoxicity. Acetaminophen toxicity may be very difficult to diagnose in young infants when suspicion for this entity is low. In addition, initial signs and symptoms are nonspecific and biochemical evidence of hepatic damage may not become evident for 24 to 36 hours. We report the case of an infant who received multiple doses of acetaminophen during an illness who developed hepatotoxicity.
Antonio E Muñiz; S Rutherfoord Rose; Steven R Liner; Robin L Foster
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric emergency care     Volume:  20     ISSN:  1535-1815     ISO Abbreviation:  Pediatr Emerg Care     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-01     Completed Date:  2005-11-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8507560     Medline TA:  Pediatr Emerg Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  824-8     Citation Subset:  IM    
Department of Emergency Medicine and Pediatrics, Virginia Commonwealth University Health System, Richmond, VA 23298-0401, USA.
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MeSH Terms
Acetaminophen / poisoning*
Analgesics, Non-Narcotic / poisoning*
Drug-Induced Liver Injury / etiology*
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 103-90-2/Acetaminophen
Comment In:
Pediatr Emerg Care. 2005 Oct;21(10):703-4   [PMID:  16215480 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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