Document Detail

Unstable angina: status of aspirin and other forms of therapy.
MedLine Citation:
PMID:  3905054     Owner:  NLM     Status:  MEDLINE    
A randomized, double-blind clinical trial in 1266 men with unstable angina showed that 324 mg of aspirin daily for 12 weeks reduced the incidence of myocardial infarction by 51% (p = .001), and the data suggested a similar reduction in mortality. The only other therapy for unstable angina that has been studied in randomized trials of adequate size to evaluate mortality and rate of infarction is aortocoronary bypass surgery. Results with heparin therapy have been encouraging, but the studies in which this drug has been tested have been flawed. Nitrates, beta-blockers, calcium blockers, fibrinolytic therapy, and coronary angioplasty have not been adequately evaluated. Randomized trials of aortocoronary bypass surgery have not demonstrated decreased mortality or rates of myocardial infarction in patients with unstable angina. Although surgical techniques have improved since these trials were conducted, medical management has also improved. Mortality and infarct rate in patients with unstable angina are now lower than in the early 1970s. New well-controlled clinical trials are needed.
H D Lewis
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  72     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-01-15     Completed Date:  1986-01-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  V155-60     Citation Subset:  AIM; IM    
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MeSH Terms
Angina Pectoris / drug therapy*
Angina, Unstable / drug therapy*,  therapy
Aspirin / therapeutic use*
Clinical Trials as Topic
Coronary Artery Bypass
Double-Blind Method
Follow-Up Studies
Heparin / therapeutic use
Middle Aged
Myocardial Infarction / prevention & control
Random Allocation
Time Factors
Reg. No./Substance:
50-78-2/Aspirin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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