Document Detail

Unstable angina associated with sertraline.
MedLine Citation:
PMID:  9343035     Owner:  NLM     Status:  MEDLINE    
An 81-year-old woman reported with chest pain occurring shortly after initiating treatment with sertraline. She had no prior history of cardiovascular disease. She developed nausea and malaise 4 h after her first dose, which resulted in avoidance of further treatment. After voluntarily reinitiating sertraline 10 days later, she again developed nausea and malaise but persisted with treatment. On the second day, her gastrointestinal symptoms were accompanied by crushing retrosternal chest pain radiating to both arms and resolving spontaneously after 10 mins. Following the third dose of sertraline, the patient experienced severe and persistent crushing retrosternal chest pain radiating to both arms. She was hospitalized with a diagnosis of unstable angina and treated with acetylsalicylic acid, intravenous heparin and nitroglycerin. The temporal relationship of chest pain onset following ingestion of sertraline is strongly suggestive of an adverse medication effect.
R Sunderji; N Press; H Amin; K Gin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  13     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-20     Completed Date:  1997-11-20     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  849-51     Citation Subset:  IM    
Vancouver Hospital and Health Sciences Centre, British Columbia.
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MeSH Terms
1-Naphthylamine / adverse effects,  analogs & derivatives*,  therapeutic use
Aged, 80 and over
Angina, Unstable / chemically induced*
Antidepressive Agents / adverse effects*,  therapeutic use
Serotonin Uptake Inhibitors / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors; 134-32-7/1-Naphthylamine; 79617-96-2/Sertraline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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