Document Detail

Unsaturated fatty acids are inversely associated and n-6/n-3 ratios are positively related to inflammation and coagulation markers in plasma of apparently healthy adults.
MedLine Citation:
PMID:  20097190     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Blood lipids and inflammatory markers levels have been associated with the development and progression of atherosclerosis. As the association of inflammatory markers with plasma fatty acids has not been extensively evaluated and understood, we sought to investigate the associations between dietary and plasma fatty acids with various inflammation and coagulation markers. METHODS: High sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), fibrinogen, and homocysteine were measured in serum of 374 free-living, healthy men and women, randomly selected from the ATTICA's study database. Total plasma fatty acids were determined by gas chromatography. Dietary fatty acids were assessed through a semi-quantitative FFQ. RESULTS: Multi-adjusted regression analyses revealed that plasma n-3 fatty acids were inversely associated with CRP, IL-6 and TNF-alpha; plasma n-6 fatty acids were inversely associated with CRP, IL-6 and fibrinogen; monounsaturated fatty acids were inversely associated with CRP and IL-6 (all p-values<0.05). Interestingly, the n-6/n-3 ratios exhibited the strongest positive correlations with all the markers studied. No associations were observed between dietary fatty acids and the investigated markers. CONCLUSIONS: Measurements of total plasma fatty acids could provide insights into the relationships between diet and atherosclerotic disease. Moreover, the n-6/n-3 ratio may constitute a predictor of low-grade inflammation and coagulation.
Nick Kalogeropoulos; Demosthenes B Panagiotakos; Christos Pitsavos; Christina Chrysohoou; Georgia Rousinou; Marina Toutouza; Christodoulos Stefanadis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-26
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  411     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  584-91     Citation Subset:  IM    
Copyright Information:
2010 Elsevier B.V. All rights reserved.
Department of Nutrition Science - Dietetics, Harokopio University, Athens, Greece.
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MeSH Terms
Biological Markers / blood
Blood Coagulation
C-Reactive Protein / analysis
Chromatography, Gas
Dietary Supplements
Fatty Acids, Omega-3 / blood*
Fatty Acids, Omega-6 / blood*
Fibrinogen / analysis
Homocysteine / blood
Interleukin-6 / blood
Reference Values
Regression Analysis
Sensitivity and Specificity
Tumor Necrosis Factor-alpha / blood
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 454-28-4/Homocysteine; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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