Document Detail

Unruptured intracranial aneurysms in the Familial Intracranial Aneurysm and International Study of Unruptured Intracranial Aneurysms cohorts: differences in multiplicity and location.
MedLine Citation:
PMID:  22540404     Owner:  NLM     Status:  MEDLINE    
OBJECT: Familial predisposition is a recognized nonmodifiable risk factor for the formation and rupture of intracranial aneurysms (IAs). However, data regarding the characteristics of familial IAs are limited. The authors sought to describe familial IAs more fully, and to compare their characteristics with a large cohort of nonfamilial IAs.
METHODS: The Familial Intracranial Aneurysm (FIA) study is a multicenter international study with the goal of identifying genetic and other risk factors for formation and rupture of IAs in a highly enriched population. The authors compared the FIA study cohort with the International Study of Unruptured Intracranial Aneurysms (ISUIA) cohort with regard to patient demographic data, IA location, and IA multiplicity. To improve comparability, all patients in the ISUIA who had a family history of IAs or subarachnoid hemorrhage were excluded, as well as all patients in both cohorts who had a ruptured IA prior to study entry.
RESULTS: Of 983 patients enrolled in the FIA study with definite or probable IAs, 511 met the inclusion criteria for this analysis. Of the 4059 patients in the ISUIA study, 983 had a previous IA rupture and 657 of the remainder had a positive family history, leaving 2419 individuals in the analysis. Multiplicity was more common in the FIA patients (35.6% vs 27.9%, p<0.001). The FIA patients had a higher proportion of IAs located in the middle cerebral artery (28.6% vs 24.9%), whereas ISUIA patients had a higher proportion of posterior communicating artery IAs (13.7% vs 8.2%, p=0.016).
CONCLUSIONS: Heritable structural vulnerability may account for differences in IA multiplicity and location. Important investigations into the underlying genetic mechanisms of IA formation are ongoing.
Jason Mackey; Robert D Brown; Charles J Moomaw; Laura Sauerbeck; Richard Hornung; Dheeraj Gandhi; Daniel Woo; Dawn Kleindorfer; Matthew L Flaherty; Irene Meissner; Craig Anderson; E Sander Connolly; Guy Rouleau; David F Kallmes; James Torner; John Huston; Joseph P Broderick;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-27
Journal Detail:
Title:  Journal of neurosurgery     Volume:  117     ISSN:  1933-0693     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-03     Completed Date:  2012-09-12     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  60-4     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Cohort Studies
International Cooperation
Intracranial Aneurysm / classification,  epidemiology*,  genetics*
Middle Aged
Middle Cerebral Artery / pathology
Posterior Cerebral Artery / pathology
Risk Factors
Sex Factors
Grant Support
Robert D Brown / ; James Torner / ; Joseph P Broderick /
Erratum In:
J Neurosurg. 2012 Jul;117(1):192

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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