Document Detail

Unruptured intracranial aneurysm as a cause of cerebral ischemia.
MedLine Citation:
PMID:  20926179     Owner:  NLM     Status:  In-Process    
BACKGROUND: Unruptured intracranial artery aneurysms (IAs) can be revealed by cerebral ischemia. Little is known on the clinical course and outcome of patients with this condition. We report our findings in a consecutive series of 15 such patients.
METHODS: We retrospectively analyzed patients with ischemic stroke (IS) or transient ischemic attack (TIA), unruptured IA on the symptomatic cerebral artery, and no other potential cause of cerebral ischemia consecutively treated in a tertiary stroke unit.
RESULTS: Fifteen patients (ten women, and five men) were identified. Their mean age was 49.7 years (range, 37-80 years). Ten patients presented with IS, and five with TIA. The median diameter of IA was 7.5mm (range, 2.5-23 mm). Aneurysm thrombosis was found on imaging in 9/10 patient with IS, and 1/5 patients with TIA (p=0.017). Thirteen patients were given an antiplatelet agent. Mean follow-up until last visit or treatment of aneurysm was 393 days (median 182 days; range, 6-1825 days). There was no ischemic recurrence. Partial or complete recanalization of aneurysm thrombosis occurred in 7/10 patients. Two patients, both with initial aneurysmal thrombosis and on antiplatelet therapy, experienced aneurysm rupture.
CONCLUSION: Unruptured IA is a rare cause of IS/TIA. IS is associated with aneurysm thrombosis. Our findings suggest that aneurysm thrombosis is a dynamic process which is associated with a low rate of ischemic recurrence on antiplatelet therapy but may be followed by subarachnoid hemorrhage.
L Calviere; A Viguier; N A Da Silva; C Cognard; V Larrue
Related Documents :
15674659 - Relapsing arterial aneurysms in juvenile behçet's disease.
9445349 - Apoptosis of medial smooth muscle cells in the development of saccular cerebral aneurys...
7114769 - Popliteal artery aneurysm.
471229 - Giant aneurysms of the posterior fossa suspected as neoplasms on computed tomography.
11311909 - Characteristics of aneurysms arising from the horizontal portion of the anterior cerebr...
15221249 - Endoscope-assisted microneurosurgery for anterior circulation aneurysms using the angle...
19881389 - Relationship of cardiac involvement with arterial stiffness in a general population of ...
16506349 - Comparative safety and efficacy of urokinase and recombinant tissue plasminogen activat...
18786139 - An extremely uncommon variation of left hepatic artery around the esophagus: a case rep...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  113     ISSN:  1872-6968     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  28-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Department of Neurology, Toulouse University, Toulouse, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A plea to young surgeons dealing with radical prostatectomy patients: invest your time and intellect...
Next Document:  Spinal meningiomas: age-related features.