Document Detail

Unresponsiveness to L-DOPA in parkinsonian patients: a study of homovanillic acid concentration in the cerebrospinal fluid.
MedLine Citation:
PMID:  2475587     Owner:  NLM     Status:  MEDLINE    
In this study, concentrations of homovanillic acid (HVA), a principal metabolite of dopamine (DA), in the cerebrospinal fluid (CSF) were measured in 17 patients with Parkinson's disease (PD) who had been effectively treated with L-DOPA and in 8 patients clinically diagnosed as having striatonigral degeneration (SND) and for whom treatment with L-DOPA had proved ineffective. L-DOPA administration, consisting of a daily dosage of 600 mg plus 150 mg aromatic L-amino acid decarboxylase inhibitor was continued in all cases for at least 3 months. In the PD group, the HVA value was 511.6 +/- 196.5 pmol/ml and in the SND group, 144.9 +/- 83.4 pmol/ml. This remarkably low value for the SND group suggests that there may exist severe disorders in the uptake and decarboxylation of exogenous L-DOPA.
K Nishi; T Kondo; H Narabayashi; H Takubo; S Muramoto; H Araki
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  92     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-09-27     Completed Date:  1989-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
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MeSH Terms
Biological Markers / cerebrospinal fluid*
Homovanillic Acid / cerebrospinal fluid*
Hydroxyindoleacetic Acid / cerebrospinal fluid
Levodopa / blood,  diagnostic use,  therapeutic use*
Methoxyhydroxyphenylglycol / cerebrospinal fluid
Parkinson Disease / cerebrospinal fluid,  drug therapy*
Reg. No./Substance:
0/Biological Markers; 0/Levodopa; 306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

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