Document Detail


Unresponsiveness of mu-opioid receptor knockout mice to lipopolysaccharide-induced fever.
MedLine Citation:
PMID:  15700026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently, we demonstrated that lipopolysaccharide (LPS)-induced fever could be suppressed by a selective mu-opioid receptor antagonist, indicating that the mu-opioid system is involved in the LPS fever. In the present study, to confirm the role of the mu-opioid system in the pathogenesis of LPS fever, we used mice lacking the mu-opioid receptor. In the wild type (WT), following intraperitoneal (i.p.) injection of 100 microg kg(-1) of LPS, body temperature (T(b)) increased approximately 1 degrees C and remained elevated during the 360-min recording period. In the mu-opioid receptor knockout (MOR-KO) mice, the administration of 100 microg kg(-1) i.p. of LPS did not induce fever during the recording period. Saline by itself, given i.p., did not alter the T(b), either in WT or MOR-KO. These results confirm that the mu-opioid system is involved in LPS-induced fever.
Authors:
Khalid Benamar; Malgorzata McMenamin; Ellen B Geller; Young G Chung; John E Pintar; Martin W Adler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of pharmacology     Volume:  144     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-18     Completed Date:  2005-07-29     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1029-31     Citation Subset:  IM    
Affiliation:
Center for Substance Abuse Research, Temple University School of Medicine, 3400 N. Broad Street, Philadelphia, PA 19140, USA. kbenamar@temple.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature / drug effects,  genetics
Drug Tolerance / genetics*
Fever / chemically induced,  genetics*,  metabolism*
Lipopolysaccharides / toxicity*
Mice
Mice, Inbred C57BL
Mice, Knockout
Receptors, Opioid, mu / deficiency*,  genetics*,  physiology
Grant Support
ID/Acronym/Agency:
DA 06650/DA/NIDA NIH HHS; DA 13429/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Lipopolysaccharides; 0/Receptors, Opioid, mu
Comments/Corrections

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