Document Detail

Unresolved issues after the available comparative trials of thrombolytic agents in acute myocardial infarction.
MedLine Citation:
PMID:  8328188     Owner:  NLM     Status:  MEDLINE    
Although the results of GISSI-2/International Study and ISIS-3 have confirmed the safety of streptokinase, they do not contradict the view that early recanalization, inducible with a higher incidence with rt-PA, is a primary determinant of clinical outcome. A definitive answer to the question must come from large scale mortality studies of patients in whom the risk/benefit ratio of thrombolysis is not unacceptably high, in whom electrocardiographic criteria of infarction are unequivocal, and in whom treatment can be initiated early after the onset of symptoms with regimens that will induce not only early recanalization, but also sustained patency in infarct-related arteries.
D Collen
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Zeitschrift für Kardiologie     Volume:  82 Suppl 2     ISSN:  0300-5860     ISO Abbreviation:  Z Kardiol     Publication Date:  1993  
Date Detail:
Created Date:  1993-08-09     Completed Date:  1993-08-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0360430     Medline TA:  Z Kardiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  IM    
Center for Thrombosis and Vascular Research, University of Leuven, Belgium.
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MeSH Terms
Cerebrovascular Disorders / mortality
Clinical Trials as Topic*
Fibrinolytic Agents / adverse effects,  therapeutic use*
Hospital Mortality
Myocardial Infarction / drug therapy*,  mortality
Survival Rate
Thrombolytic Therapy*
Reg. No./Substance:
0/Fibrinolytic Agents

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