Document Detail


Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.
MedLine Citation:
PMID:  21274877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: These data confirm and extend previous observations regarding the high (18%) prevalence of unrecognized or uncertain acetaminophen toxicity among subjects with indeterminate acute liver failure. N-Acetylcysteine use was limited in this group, presumably because of the lack of a specific diagnosis of acetaminophen toxicity.
Authors:
Niraj Khandelwal; Laura P James; Corron Sanders; Anne M Larson; William M Lee;
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-01-10
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  53     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-28     Completed Date:  2011-03-18     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  567-76     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Association for the Study of Liver Diseases.
Affiliation:
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8887, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / adverse effects*
Acetylcysteine / therapeutic use
Adult
Analgesics, Non-Narcotic / adverse effects*
Bilirubin / blood
Drug Overdose
Drug-Induced Liver Injury / blood,  diagnosis*,  drug therapy
Female
Free Radical Scavengers / therapeutic use
Humans
Liver Failure, Acute / blood,  chemically induced*,  diagnosis*
Male
Middle Aged
Prognosis
Retrospective Studies
Severity of Illness Index
Survival Rate
Transaminases / blood
Grant Support
ID/Acronym/Agency:
DK U-01-58369/DK/NIDDK NIH HHS; R01 DK058369-05/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Free Radical Scavengers; 103-90-2/Acetaminophen; 616-91-1/Acetylcysteine; 635-65-4/Bilirubin; EC 2.6.1.-/Transaminases
Comments/Corrections
Comment In:
Hepatology. 2011 Aug;54(2):746-7   [PMID:  21360569 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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