Document Detail

Unravelling hair follicle-adipocyte communication.
MedLine Citation:
PMID:  23163647     Owner:  NLM     Status:  MEDLINE    
Here, we explore the established and potential roles for intradermal adipose tissue in communication with hair follicle biology. The hair follicle delves deep into the rich dermal macroenvironment as it grows to maturity where it is surrounded by large lipid-filled adipocytes. Intradermal adipocytes regenerate with faster kinetics than other adipose tissue depots and in parallel with the hair cycle, suggesting an interplay exists between hair follicle cells and adipocytes. While adipocytes have well-established roles in metabolism and energy storage, until recently, they were overlooked as niche cells that provide important growth signals to neighbouring skin cells. We discuss recent data supporting adipocytes as niche cells for the skin and skin pathologies that may be related to alterations in skin adipose tissue defects.
Barbara Schmidt; Valerie Horsley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Experimental dermatology     Volume:  21     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-03-26     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  827-30     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Department of Molecular, Cell and Developmental Biology, Yale Stem Cell Center, Yale University, New Haven, CT, USA.
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MeSH Terms
Adipocytes / cytology*,  physiology
Alopecia / physiopathology
Cell Communication / physiology*
Disease Models, Animal
Hair Follicle / cytology*,  growth & development,  physiology
Hypertrichosis / physiopathology
Regeneration / physiology
Skin Physiological Phenomena*
Grant Support

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