Document Detail

Unraveling virus-induced lymphomagenesis.
MedLine Citation:
PMID:  21339638     Owner:  NLM     Status:  MEDLINE    
Kaposi sarcoma herpesvirus (KSHV), a human gammaherpesvirus, is the etiological agent for the endothelial-derived Kaposi sarcoma (KS) and also for certain lymphoproliferative disorders. In these lymphoproliferations, the KSHV-infected cells carry the stigmata of B lymphocytes, with plasmablastic features. The JCI has published three manuscripts addressing key questions related to B cell infection and viral latent expression in B cells. Myoung and Ganem provide evidence that CD4(+) lymphocytes suppress KSHV replication, promoting latency in B cells; Hassman and colleagues show that KSHV infection drives plasmablast differentiation in a subset of IgM(+) λ light chain-expressing cells; and Ballon and colleagues describe the in vivo transdifferentiation of B lymphocytes by KSHV-encoded viral FLICE-inhibitory protein (vFLIP).
Chris Boshoff
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Publication Detail:
Type:  Comment; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-21
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  121     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-02     Completed Date:  2011-04-27     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  838-41     Citation Subset:  AIM; IM    
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MeSH Terms
B-Lymphocytes / virology*
CASP8 and FADD-Like Apoptosis Regulating Protein / metabolism
CD4-Positive T-Lymphocytes / virology*
Cell Differentiation
Disease Models, Animal
Herpesvirus 8, Human / metabolism*
Immunoglobulin M / immunology
Mice, Transgenic
NF-kappa B / metabolism
Plasma Cells / virology
Virus Latency / genetics
Grant Support
G0800168//Medical Research Council; //Cancer Research UK; //Medical Research Council
Reg. No./Substance:
0/CASP8 and FADD-Like Apoptosis Regulating Protein; 0/Immunoglobulin M; 0/NF-kappa B
Comment On:
J Clin Invest. 2011 Mar;121(3):1130-40   [PMID:  21339648 ]
J Clin Invest. 2011 Mar;121(3):1141-53   [PMID:  21339646 ]
J Clin Invest. 2011 Feb;121(2):752-68   [PMID:  21245574 ]

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