| Unraveling pancreatic islet biology by quantitative proteomics. | |
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MedLine Citation:
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PMID: 21819304 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The pancreatic islets of Langerhans play a critical role in maintaining blood glucose homeostasis by secreting insulin and several other important peptide hormones. Impaired insulin secretion due to islet dysfunction is linked to the pathogenesis underlying both Type 1 and Type 2 diabetes. Over the past 5 years, emerging proteomic technologies have been applied to dissect the signaling pathways that regulate islet functions and gain an understanding of the mechanisms of islet dysfunction relevant to diabetes. Herein, we briefly review some of the recent quantitative proteomic studies involving pancreatic islets geared towards gaining a better understanding of islet biology relevant to metabolic diseases. |
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Authors:
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Jian-Ying Zhou; Geoffrey P Dann; Chong Wee Liew; Richard D Smith; Rohit N Kulkarni; Wei-Jun Qian |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of proteomics Volume: 8 ISSN: 1744-8387 ISO Abbreviation: Expert Rev Proteomics Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101223548 Medline TA: Expert Rev Proteomics Country: England |
Other Details:
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Languages: eng Pagination: 495-504 Citation Subset: IM |
Affiliation:
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Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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