Document Detail


Unraveling the mechanism of BRCA2 in homologous recombination.
MedLine Citation:
PMID:  21731065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BRCA2 is the product of a breast cancer susceptibility gene in humans and the founding member of an emerging family of proteins present throughout the eukaryotic domain that serve in homologous recombination. The function of BRCA2 in recombination is to control RAD51, a protein that catalyzes homologous pairing and DNA strand exchange. By physically interacting with both RAD51 and single-stranded DNA, BRCA2 mediates delivery of RAD51 preferentially to sites of single-stranded DNA (ssDNA) exposed as a result of DNA damage or replication problems. Through its action, BRCA2 helps restore and maintain integrity of the genome. This review highlights recent studies on BRCA2 and its orthologs that have begun to illuminate the molecular mechanisms by which these proteins control homologous recombination.
Authors:
William K Holloman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-07-06
Journal Detail:
Title:  Nature structural & molecular biology     Volume:  18     ISSN:  1545-9985     ISO Abbreviation:  Nat. Struct. Mol. Biol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-06     Completed Date:  2011-09-07     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101186374     Medline TA:  Nat Struct Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  748-54     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, Weill Cornell Cancer Center, Weill Cornell Medical College, New York, New York, USA. wkhollo@med.cornell.edu
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MeSH Terms
Descriptor/Qualifier:
BRCA2 Protein / chemistry,  genetics,  physiology*
Binding Sites
DNA Damage
DNA Repair*
DNA, Single-Stranded / chemistry
Models, Genetic*
Protein Structure, Tertiary
Rad51 Recombinase / chemistry,  genetics,  physiology
Recombination, Genetic*
Grant Support
ID/Acronym/Agency:
GM042482/GM/NIGMS NIH HHS; GM079859/GM/NIGMS NIH HHS; R01 GM042482/GM/NIGMS NIH HHS; R01 GM079859/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/BRCA2 Protein; 0/DNA, Single-Stranded; EC 2.7.7.-/Rad51 Recombinase
Comments/Corrections

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