Document Detail


Unprotected left main stenting in the real world: five-year outcomes of the French Left Main Taxus registry.
MedLine Citation:
PMID:  23014945     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aims: Limited long-term data are available to support drug-eluting stent (DES) unprotected left main (LM) intervention. We sought to evaluate long-term outcomes of LM intervention with paclitaxel-eluting stents. Methods and results: In this prospective multicentre registry, 291 patients with unprotected LM stenosis underwent percutaneous revascularisation with the TAXUS® Express® stent, using a consistent technical approach for both ostial/shaft and bifurcation lesions (provisional side branch stenting). At five years (n=263), the cumulative incidence of major adverse cardiac events (MACE) and cardiac death were 23.6% and 12.5%, respectively. Myocardial infarction (MI) occurred in 16 patients (6.1%), definite stent thrombosis in 0.4%, and target lesion revascularisation (TLR) was required in 10.3%. Patients with distal LM lesions requiring two-stent procedures had increased MACE compared with those with single-stent interventions (34.1% vs. 17.8%, p=0.009). This was primarily driven by an increased incidence of cardiac death (18.2% vs. 8.5%, p=0.05). Diabetes was associated with increased TLR and was an independent predictor of MACE at five years (odds ration [OR] 2.10, 95% confidence interval [CI] 1.10-3.99, p=0.02). Conclusions: This study confirms the long-term safety and efficacy of the TAXUS® DES in unprotected LM stenting. Diabetes and need for a second stent in distal LM interventions were associated with an increased risk of adverse outcomes.
Authors:
Darren Mylotte; Brahim Meftout; Anouska Moynagh; Beatriz Vaquerizo; Olivier Darremont; Marc Silvestri; Yves Louvard; Jean-Louis Leymarie; Marie-Claude Morice; Thierry Lefèvre; Philippe Garot
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology     Volume:  -     ISSN:  1969-6213     ISO Abbreviation:  EuroIntervention     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251040     Medline TA:  EuroIntervention     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institut Cardiovasculaire Paris Sud, Institut Hospitalier Jacques-Cartier Massy, and Hopital Claude-Galien, Quincy, France.
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