| Unprotected left main stenting in the real world: five-year outcomes of the French Left Main Taxus registry. | |
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MedLine Citation:
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PMID: 23014945 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: Limited long-term data are available to support drug-eluting stent (DES) unprotected left main (LM) intervention. We sought to evaluate long-term outcomes of LM intervention with paclitaxel-eluting stents. Methods and results: In this prospective multicentre registry, 291 patients with unprotected LM stenosis underwent percutaneous revascularisation with the TAXUS® Express® stent, using a consistent technical approach for both ostial/shaft and bifurcation lesions (provisional side branch stenting). At five years (n=263), the cumulative incidence of major adverse cardiac events (MACE) and cardiac death were 23.6% and 12.5%, respectively. Myocardial infarction (MI) occurred in 16 patients (6.1%), definite stent thrombosis in 0.4%, and target lesion revascularisation (TLR) was required in 10.3%. Patients with distal LM lesions requiring two-stent procedures had increased MACE compared with those with single-stent interventions (34.1% vs. 17.8%, p=0.009). This was primarily driven by an increased incidence of cardiac death (18.2% vs. 8.5%, p=0.05). Diabetes was associated with increased TLR and was an independent predictor of MACE at five years (odds ration [OR] 2.10, 95% confidence interval [CI] 1.10-3.99, p=0.02). Conclusions: This study confirms the long-term safety and efficacy of the TAXUS® DES in unprotected LM stenting. Diabetes and need for a second stent in distal LM interventions were associated with an increased risk of adverse outcomes. |
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Authors:
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Darren Mylotte; Brahim Meftout; Anouska Moynagh; Beatriz Vaquerizo; Olivier Darremont; Marc Silvestri; Yves Louvard; Jean-Louis Leymarie; Marie-Claude Morice; Thierry Lefèvre; Philippe Garot |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-27 |
Journal Detail:
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Title: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology Volume: - ISSN: 1969-6213 ISO Abbreviation: EuroIntervention Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101251040 Medline TA: EuroIntervention Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institut Cardiovasculaire Paris Sud, Institut Hospitalier Jacques-Cartier Massy, and Hopital Claude-Galien, Quincy, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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