Document Detail

Unpredictable response to vasodilator therapy in primary pulmonary hypertension.
MedLine Citation:
PMID:  9726697     Owner:  NLM     Status:  MEDLINE    
A 49-year-old man with severe primary pulmonary hypertension unresponsive to multiple vasodilators showed beneficial response to intravenous (i.v.) isoproterenol with significant decrease in the pulmonary vascular resistance and increase in the cardiac output. However, the patient became dependent on i.v. isoproterenol and eventually died suddenly following an episode of bradyarrhythmia. Autopsy confirmed severe primary pulmonary hypertension. As the response to vasodilator therapy can be unpredictable in PPH, sequential hemodynamic evaluation of drugs is necessary for finding an optimal therapeutic agent.
M I Schmiedt; U R Shettigar; M Siddique; G Barbier; M Bialow; S Carranza
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  International journal of clinical pharmacology and therapeutics     Volume:  36     ISSN:  0946-1965     ISO Abbreviation:  Int J Clin Pharmacol Ther     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-11-20     Completed Date:  1998-11-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9423309     Medline TA:  Int J Clin Pharmacol Ther     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  435-40     Citation Subset:  IM    
VA Medical Center, University of South Florida College of Medicine, Bay Pines 33744, USA.
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MeSH Terms
Bradycardia / complications
Fatal Outcome
Hemodynamics / drug effects
Hypertension, Pulmonary / complications,  drug therapy*,  pathology
Infusions, Intravenous
Isoproterenol / therapeutic use*
Lung / drug effects,  pathology
Middle Aged
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Vasodilator Agents; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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