| Unnatural translation initiation. | |
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MedLine Citation:
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PMID: 18278847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Protein translation in nature always begins with an initiator transfer RNA (tRNA) carrying the amino acid methionine. This was circumvented in vitro with a reconstituted translation system utilizing initiator tRNA synthetically mischarged with the other natural amino acids. In addition, it was determined that this system could accommodate these non-methionine amino acids containing various N-alpha-acyl groups, many of which are useful for post-translational modification such as peptide cyclization. |
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Authors:
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John W Tomsho; Stephen J Benkovic |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: ACS chemical biology Volume: 3 ISSN: 1554-8937 ISO Abbreviation: ACS Chem. Biol. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-18 Completed Date: 2008-05-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101282906 Medline TA: ACS Chem Biol Country: United States |
Other Details:
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Languages: eng Pagination: 87-8 Citation Subset: IM |
Affiliation:
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The Pennsylvania State University, Department of Chemistry, 414 Wartik Laboratory, University Park, Pennsylvania 16802, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminoacylation Codon, Initiator Peptide Chain Initiation, Translational* Peptides, Cyclic / chemical synthesis*, chemistry RNA, Transfer, Amino Acyl / chemistry*, metabolism RNA, Transfer, Met / chemistry, metabolism* Transfer RNA Aminoacylation* |
| Chemical | |
Reg. No./Substance:
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0/Codon, Initiator; 0/G7-18NATE; 0/Peptides, Cyclic; 0/RNA, Transfer, Amino Acyl; 0/RNA, Transfer, Met |
| Comments/Corrections | |
Comment On:
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ACS Chem Biol. 2008 Feb 15;3(2):120-9
[PMID:
18215017
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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