| Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. | |
| | |
MedLine Citation:
|
PMID: 9174474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Periconceptual consumption of folic acid has been shown to decrease the incidence of neural tube defects. The strategy of universal fortification of staple foodstuffs with folic acid presents the possibility of life-long exposure to unmetabolized folic acid. Chief among the risks of exposure to folic acid in the circulation is that of masking the diagnosis of cobalamin deficiency in pernicious anemia and the progression of neurologic disease. Other effects are unknown. For instance, the effect of in vivo chronic exposure of adult and fetal cells to the synthetic form of the vitamin has never been investigated at the population level. This study examined the acute appearance of unmetabolized folic acid in serum in response to the consumption of some fortified foodstuffs by young and elderly volunteers. Subjects on a 5-d regimen of fortified ready-to-eat-cereal and bread in addition to their normal diet had a threshold intake of 266 micrograms folic acid per meal at which unaltered folic acid appeared in the serum. Subjects given folic acid in either isotonic saline, milk, or white bread also had a threshold > 200 micrograms. From patterns of food consumption in the United States, the implementation of flour fortification at 1.4 mg/kg is unlikely to lead to folic acid appearance in serum, assuming that consumption is spread throughout the day. Increasing this level of fortification, however, as has been advocated by some agencies, may result in the repeated appearance of folic acid in serum over many years, particularly in consumers in nontargeted populations of large amounts of fortified foods. The "safe level of intake" of 1 mg folate/d set by the US Food and Drug Administration may cause a serum folic acid effect. Furthermore, a repeated serum folic acid response is likely to be found in many women complying with the advice to take 400 micrograms folic acid/d to prevent the occurrence of neural tube defects. |
| | |
Authors:
|
P Kelly; J McPartlin; M Goggins; D G Weir; J M Scott |
Related Documents
:
|
11252704 - College women's awareness and consumption of folic acid for the prevention of neural tu... 1130304 - Prevention of folate deficiency by food fortification. iii. effect in pregnant subjects... 19203954 - Influences of aging and cloning methods on the capacity for somatic embryogenesis of a ... 8464794 - Evaluation of egg injection of folic acid and effect of supplemental folic acid on hatc... 2131944 - The gastric acid conundrum in peptic ulcer. 17597904 - Multi-class subcellular location prediction for bacterial proteins. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: 65 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1997 Jun |
Date Detail:
|
Created Date: 1997-06-24 Completed Date: 1997-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1790-5 Citation Subset: AIM; IM |
Affiliation:
|
Vitamin Research, Sir Patrick Duns Trinity College Laboratory, St James Hospital, Dublin, Ireland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Aging / blood, physiology Analysis of Variance Animals Bread / analysis Centers for Disease Control and Prevention (U.S.) Cereals / chemistry Dose-Response Relationship, Drug Female Folic Acid / analysis, blood*, pharmacology* Food, Fortified* Humans Incidence Isotonic Solutions / chemistry Male Middle Aged Milk / chemistry Neural Tube Defects / epidemiology, prevention & control Sodium Chloride / chemistry United States United States Food and Drug Administration |
| Chemical | |
Reg. No./Substance:
|
0/Isotonic Solutions; 59-30-3/Folic Acid; 7647-14-5/Sodium Chloride |
| Comments/Corrections | |
Comment In:
|
Am J Clin Nutr. 1997 Dec;66(6):1480-1
[PMID:
9394705
]
Am J Clin Nutr. 1997 Jun;65(6):1889-90 [PMID: 9174489 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Breath-hydrogen production and amylose content of the diet.
Next Document: Serum beta-carotene and vitamin C as biomarkers of vegetable and fruit intakes in a community-based ...