Document Detail


Unmasking of carnitine palmitoyltransferase deficiency during an acute exacerbation of asthma complicated by rhabdomyolysis in a soldier.
MedLine Citation:
PMID:  15532348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rhabdomyolysis is a life-threatening condition that may result from various etiologies. We report a rare case of severe rhabdomyosis in a soldier after a mild acute asthma exacerbation. Further work-up revealed an underlying deficiency of type II carnitine palmitoyltransferase. The case is discussed along with a review of the literature. It is concluded that acute asthma exacerbations may be a unique precipitating factor of rhabdomyolysis and may therefore unmask underlying metabolic myopathies. Asthma may cause rhabdomyolysis through several different mechanisms, and thus the occurrence of rhabdomyolysis in the context of asthma exacerbations should warrant a work-up for metabolic diseases, especially in the presence of high creatine kinase levels. Given the high incidence of asthma, especially among young adults, a high index of suspicion is needed in order that rhabdomyolysis be promptly diagnosed and treated.
Authors:
Jacob Gilad; Avinoam Pirogovsky; Carmi Bartal
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Military medicine     Volume:  169     ISSN:  0026-4075     ISO Abbreviation:  Mil Med     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-11-09     Completed Date:  2004-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984771R     Medline TA:  Mil Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  821-3     Citation Subset:  IM    
Affiliation:
Division of Internal Medicine, Soroka University Medical Center, Beer-Sheva, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Asthma / epidemiology*
Carnitine O-Palmitoyltransferase / deficiency*
Humans
Male
Metabolic Diseases / diagnosis,  epidemiology*
Military Personnel
Rhabdomyolysis / epidemiology*
Chemical
Reg. No./Substance:
EC 2.3.1.21/Carnitine O-Palmitoyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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