Document Detail

Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22.
MedLine Citation:
PMID:  22961652     Owner:  NLM     Status:  Publisher    
Apart from conventional CD4(+) Th17 cells, the cytokines IL-17A and IL-22 can also be produced by γδ T cells, NK cells and lymphoid tissue inducer (LTi) cells. Th17 cells develop from precursor cells after TCR stimulation in the presence of TGF-β, IL-6 and IL-23. In contrast, a subset of γδ T cells ("γδT17") is committed for fast IL-17 production already in the thymus; however, γδ T cells can also produce IL-17 after prolonged in vitro stimulation via their γδ TCR plus IL-23. Here, we show that γδ T-, LTi- and NKT- cells differ extensively from Th17 cells in their signalling requirements for the generation of IL-17A and IL-22. While production of these cytokines by Th17 cells totally depends on the transcription factor Interferon-Regulatory-Factor 4 (IRF4), IRF4 is irrelevant in the other cell types. As for γδ T cells, this finding pertains to both thymic commitment and prolonged in vitro culture. Furthermore, IL-17A-producing γδ T cells accumulate in the CNS of IRF4 deficient (Irf4(-/-) ) mice during experimental autoimmune encephalomyelitis. IL-17A-producing wt and Irf4(-/-) γδ T cells equally express CCR6 and lack CD27. The underlying IRF4 independent pathway partially involves STAT3 during in vitro stimulation.
Hartmann Raifer; Azita J Mahiny; Nadine Bollig; Franziska Petermann; Anne Hellhund; Kerstin Kellner; Anna Guralnik; Katharina Reinhard; Evita Bothur; Magdalena Huber; Stefan Bauer; Max Löhning; Elina A Kiss; Stephanie C Ganal; Andreas Diefenbach; Thomas Korn; Michael Lohoff
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-7
Journal Detail:
Title:  European journal of immunology     Volume:  -     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Institut für medizinische Mikrobiologie und Krankenhaushygiene.
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