| Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22. | |
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MedLine Citation:
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PMID: 22961652 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Apart from conventional CD4(+) Th17 cells, the cytokines IL-17A and IL-22 can also be produced by γδ T cells, NK cells and lymphoid tissue inducer (LTi) cells. Th17 cells develop from precursor cells after TCR stimulation in the presence of TGF-β, IL-6 and IL-23. In contrast, a subset of γδ T cells ("γδT17") is committed for fast IL-17 production already in the thymus; however, γδ T cells can also produce IL-17 after prolonged in vitro stimulation via their γδ TCR plus IL-23. Here, we show that γδ T-, LTi- and NKT- cells differ extensively from Th17 cells in their signalling requirements for the generation of IL-17A and IL-22. While production of these cytokines by Th17 cells totally depends on the transcription factor Interferon-Regulatory-Factor 4 (IRF4), IRF4 is irrelevant in the other cell types. As for γδ T cells, this finding pertains to both thymic commitment and prolonged in vitro culture. Furthermore, IL-17A-producing γδ T cells accumulate in the CNS of IRF4 deficient (Irf4(-/-) ) mice during experimental autoimmune encephalomyelitis. IL-17A-producing wt and Irf4(-/-) γδ T cells equally express CCR6 and lack CD27. The underlying IRF4 independent pathway partially involves STAT3 during in vitro stimulation. |
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Authors:
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Hartmann Raifer; Azita J Mahiny; Nadine Bollig; Franziska Petermann; Anne Hellhund; Kerstin Kellner; Anna Guralnik; Katharina Reinhard; Evita Bothur; Magdalena Huber; Stefan Bauer; Max Löhning; Elina A Kiss; Stephanie C Ganal; Andreas Diefenbach; Thomas Korn; Michael Lohoff |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-7 |
Journal Detail:
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Title: European journal of immunology Volume: - ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Institut für medizinische Mikrobiologie und Krankenhaushygiene. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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