| Unkei-to for correcting luteal phase defects. | |
| | |
MedLine Citation:
|
PMID: 14562640 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess the clinical efficacy of Unkei-to in women with luteal phase defects. STUDY DESIGN: A study of 103 consecutive subjects with luteal phase defects treated with unkei-to (7.5 g/d) and 94 control subjects was conducted. A venous blood sample was taken, and plasma gonadotropins, 17 beta-estradiol and progesterone levels were measured. Dominant follicle size and endometrial thickness were assessed in the late follicular phase. RESULTS: Unkei-to significantly decreased plasma luteinizing hormone and significantly increased 17 beta-estradiol concentration in the follicular phase and significantly increased progesterone (66.7%) in the midluteal phase (P < .05). Significant development of the dominant follicle (P < .01) and endometrium (P < .001) was also observed in patients treated with unkei-to. We observed significant prolongation of the luteal phase (43%, P < .001) as measured by basal body temperature. There was a 79.6% rate of correction of luteal phase defects in patients treated with unkei-to. Furthermore, the pregnancy rate in patients desiring pregnancy was 49.5% (41/83). CONCLUSION: Administration of unkei-to may normalize the gonadotropin-ovarian endocrine system and/or their interaction in the follicular phase and may improve the endocrine environment in the luteal phase in patients with luteal phase defects. |
| | |
Authors:
|
Takahisa Ushiroyama; Atsushi Ikeda; Satoko Higashio; Toshimitsu Hosotani; Hidetoshi Yamashita; Yoshiki Yamashita; Yoshihiko Suzuki; Minoru Ueki |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: The Journal of reproductive medicine Volume: 48 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2003 Sep |
Date Detail:
|
Created Date: 2003-10-17 Completed Date: 2004-01-23 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: United States |
Other Details:
|
Languages: eng Pagination: 729-34 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan. gyn003@poh.osaka-med.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Body Temperature Drugs, Chinese Herbal / therapeutic use* Endometrium / drug effects Estradiol / blood Female Follicle Stimulating Hormone / blood Follicular Phase Humans Luteal Phase* / drug effects Luteinizing Hormone / blood Menstruation Disturbances / drug therapy* Ovarian Follicle / drug effects, physiology Ovulation / drug effects Pregnancy Progesterone / blood Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Drugs, Chinese Herbal; 0/unkei-to; 50-28-2/Estradiol; 57-83-0/Progesterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Obstetric and gynecologic complications in women with Marfan syndrome.
Next Document: Association of an A allele for interleukin-10 -627 gene promoter polymorphism with higher susceptibi...