Document Detail

The University of Ottawa Heart Institute Cardiac Transplant Program: the first 100 transplants. A pathologic study of the explanted hearts.
MedLine Citation:
PMID:  1574494     Owner:  NLM     Status:  MEDLINE    
Since 1984, 122 orthotopic heart transplants have been performed at the University of Ottawa Heart Institute. Of the 114 adult patients, 100 (87.8%) were males and 14 (12.2%) females, with mean ages of 45.8 and 47.9 yr, respectively. The hearts of these adults were pathologically diagnosed as chronic ischemic heart disease (CIHD) in 55 (48.2%), acute ischemic heart disease (AIHD) in 17 (14.9%), dilated cardiomyopathy (DC) in 30 (26.3%), valvular heart disease in five (4.4%), congenital heart disease in three (2.6%), myocarditis in three (2.6%), and other in one (0.9%) of the cases. The adult hearts (94) among the first 100 transplants were studied morphologically, to look for differences among the three major groups with clinical "end-stage" heart failure. The mean heart weights were 435, 356, and 463 gm in the CIHD, AIHD, and DC groups, respectively, with AIHD less than CIHD or DC (p less than 0.01). The ventricular wall thicknesses were similar in CIHD and DC, but the left ventricular (LV) wall thicknesses in AIHD were more than in CIHD or DC (p less than 0.01). The ventricular diameters were greater in DC than in CIHD or AIHD (p less than 0.01) and greater in CIHD than in AIHD (p less than 0.01). The mean LV cavity volumes were 158, 94, and 200 ml in CIHD, AIHD, and DC, respectively, with DC greater than in CIHD or AIHD (p less than 0.01) and CIHD greater than in AIHD (p less than 0.01). The relative differences in AIHD compared to CIHD and DC are referrable to the shorter duration of disease in the acute ischemic group.2+ off
A L Wolfsohn; V M Walley; R A Davies; C A Keon; M Khalili; W J Keon
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  5     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-06-03     Completed Date:  1992-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  158-64     Citation Subset:  IM    
Department of Pathology, Medicine and Surgery, University of Ottawa, Canada.
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MeSH Terms
Acute Disease
Cardiomyopathy, Dilated / pathology
Child, Preschool
Chronic Disease
Coronary Disease / pathology
Heart Diseases / pathology*,  therapy
Heart Transplantation*
Heart Valve Diseases / pathology
Infant, Newborn
Middle Aged
Myocardium / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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