Document Detail


Universal versus selective iron supplementation for infants and the risk of unintentional poisoning in young children: a comparative study of two populations.
MedLine Citation:
PMID:  17341538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Iron continues to be a common cause of poisoning in young children, in part due to its widespread use and easy accessibility. OBJECTIVE: To determine differences in the epidemiology and outcome of unintentional iron ingestion by young children in populations practicing selective (eg, US) versus universal (eg, Israel) iron supplementation to infants. METHODS: All cases of unintentional iron ingestion in children younger than 7 years in a one year period were identified through the poison control center databases of 2 sites (Illinois and Israel). Parameters compared include patient sex and age; type, form, and dose of iron preparation; circumstances and clinical manifestations; management; and outcome. RESULTS: A total of 602 children were identified: 459 in Illinois and 143 in Israel. The majority of Illinois children ingested multivitamin preparations (94%), whereas Israeli children ingested single-ingredient iron preparations (78%) (p < 0.001). Iron doses ingested were higher in Israel (median 14.5 vs 6.6 mg/kg; p < 0.001) but remained within the nontoxic range for most children. No deaths or severe poisonings were reported, and 93% of children in both groups were asymptomatic. The majority of ingestions in both locations were due to unintentional self-ingestion. However, parental miscalculation occurred more frequently in Israel (16%) than in Illinois (1%). CONCLUSIONS: Universal iron supplementation to infants was not associated with a negative impact on the outcome of pediatric unintentional ingestions. Low-dose exposures were safely managed by on-site observation.
Authors:
Yaron Finkelstein; Michael S Wahl; Yedidia Bentur; Tal Schechter; Ben Zion Garty; Timothy B Erickson; Gabby Chodick; Alfred Cahana; Bill J Mounstephen; Gideon Koren; Steven E Aks
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-06
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  41     ISSN:  1542-6270     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-14     Completed Date:  2007-05-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  414-9     Citation Subset:  IM    
Affiliation:
The Toxikon Consortium, Children's Memorial Hospital, Chicago, IL, USA.
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / prevention & control
Child, Preschool
Dietary Supplements / poisoning*
Female
Humans
Illinois / epidemiology
Infant
Iron / poisoning*,  therapeutic use
Israel / epidemiology
Male
Medication Errors / statistics & numerical data
Parents
Poison Control Centers / statistics & numerical data
Vitamins / poisoning*,  therapeutic use
Chemical
Reg. No./Substance:
0/Vitamins; 7439-89-6/Iron

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