Document Detail

Universal occurrence of glomerular abnormalities in patients receiving liver transplants.
MedLine Citation:
PMID:  1562023     Owner:  NLM     Status:  MEDLINE    
We conducted a prospective study of renal histology and function in 18 consecutive nonalcoholic patients who underwent orthotopic liver transplantation (OLT). Despite well-preserved renal function, all patients had abnormal renal biopsies. Four patterns of glomerular injury were identified: minor glomerular abnormalities (eight patients), hepatic glomerulosclerosis (seven), membranoproliferative glomerulonephritis (one), and IgA nephropathy (one). In one patient there was insufficient tissue to allow classification. There was a trend toward lower plasma bilirubin and higher plasma albumin in patients with minor glomerular abnormalities than in the group of patients with more severe forms of glomerular injury (29 v 82 mumol/L, 35.5 v 30 g/L; P = 0.1, 0.1 greater than P greater than 0.05, respectively). Glomerular changes persisted in the three patients who died within 7 weeks post-OLT. IgM immunofluorescence was present in all biopsies and IgA in 11. IgM-containing circulating immune complexes occurred in five patients, suggesting a pathogenic role for IgM immune complex deposition. The significance of cirrhosis-associated glomerular abnormalities is not yet known. They may contribute to the hepatorenal syndrome and the renal dysfunction that occurs in up to 94% of patients post-OLT.
D H Crawford; Z H Endre; R A Axelsen; S V Lynch; G A Balderson; R W Strong; P Kerlin; L W Powell; S J Fleming
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  19     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-05-12     Completed Date:  1992-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  339-44     Citation Subset:  IM    
Joint Liver Program, University of Queensland, Australia.
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MeSH Terms
Glomerulonephritis / complications,  etiology*,  pathology
Glomerulosclerosis, Focal Segmental / complications,  etiology,  pathology
Kidney Failure, Chronic / etiology
Kidney Glomerulus / pathology*
Liver Cirrhosis / complications*,  surgery
Liver Transplantation*
Middle Aged
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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