| Universal occurrence of glomerular abnormalities in patients receiving liver transplants. | |
| | |
MedLine Citation:
|
PMID: 1562023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We conducted a prospective study of renal histology and function in 18 consecutive nonalcoholic patients who underwent orthotopic liver transplantation (OLT). Despite well-preserved renal function, all patients had abnormal renal biopsies. Four patterns of glomerular injury were identified: minor glomerular abnormalities (eight patients), hepatic glomerulosclerosis (seven), membranoproliferative glomerulonephritis (one), and IgA nephropathy (one). In one patient there was insufficient tissue to allow classification. There was a trend toward lower plasma bilirubin and higher plasma albumin in patients with minor glomerular abnormalities than in the group of patients with more severe forms of glomerular injury (29 v 82 mumol/L, 35.5 v 30 g/L; P = 0.1, 0.1 greater than P greater than 0.05, respectively). Glomerular changes persisted in the three patients who died within 7 weeks post-OLT. IgM immunofluorescence was present in all biopsies and IgA in 11. IgM-containing circulating immune complexes occurred in five patients, suggesting a pathogenic role for IgM immune complex deposition. The significance of cirrhosis-associated glomerular abnormalities is not yet known. They may contribute to the hepatorenal syndrome and the renal dysfunction that occurs in up to 94% of patients post-OLT. |
| | |
Authors:
|
D H Crawford; Z H Endre; R A Axelsen; S V Lynch; G A Balderson; R W Strong; P Kerlin; L W Powell; S J Fleming |
Related Documents
:
|
15489063 - The clinical and pathological characteristics of chinese elderly patients with anti-neu... 12119953 - Hypocomplementemic and normocomplementemic acute nephritis in children: a comparison wi... 9011463 - Multiple sclerosis patients have peripheral blood cd45ro+ b cells and increased intesti... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 19 ISSN: 0272-6386 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 1992 Apr |
Date Detail:
|
Created Date: 1992-05-12 Completed Date: 1992-05-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 339-44 Citation Subset: IM |
Affiliation:
|
Joint Liver Program, University of Queensland, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Biopsy Female Glomerulonephritis / complications, etiology*, pathology Glomerulosclerosis, Focal Segmental / complications, etiology, pathology Humans Kidney Failure, Chronic / etiology Kidney Glomerulus / pathology* Liver Cirrhosis / complications*, surgery Liver Transplantation* Male Middle Aged Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An audit of appropriate tests in renal biopsy coagulation screens.
Next Document: Outbreak of hemodialysis-associated non-A, non-B hepatitis and correlation with antibody to hepatiti...