| Universal leukocyte reduction of transfused red cells does not provide benefit to patients undergoing cardiac surgery. | |
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MedLine Citation:
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PMID: 17418737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: A policy of universal leukocyte reduction of the blood supply in Finland was implemented at the beginning of 2003. The aim of the present evaluation was to determine the potential role of leukocyte-reduced red blood cells in decreasing postoperative infections. DESIGN: A retrospective cohort study. SETTING: A major university clinic. PARTICIPANTS: Consecutive patients undergoing cardiac surgery during the years 2002 and 2003. INTERVENTIONS: Transfused patients received either buffy-coat-depleted red blood cells before leukocyte reduction (n = 782) or leukocyte-reduced red blood cells after leukocyte reduction (n = 632). MEASUREMENTS AND MAIN RESULTS: The evaluated outcome parameters were culture-proven postoperative infections, 90-day mortality, and length of stay in the intensive care unit. The percentage of patients transfused with red blood cells (56% v 53%, p = 0.16) and amounts of transfused red blood cells (4.3 +/- 6.7 [3.0] units v 4.3 +/- 6.6 [2.0] units, means +/- standard deviation [median], p = 0.48) were comparable between the study groups (buffy-coat-depleted group and leukocyte-reduced group, respectively). The 90-day mortality (6.6% v 6.3%, p = 0.28), the length of intensive care stay (3.6 +/- 4.7 [2.0] days v 4.3 +/- 7.1 [2.0] days, p = 0.34), and the number of patients with culture-proven infections (8.8% v 10.9%, p = 0.19) were unchanged after universal leukocyte reduction. In multivariate comparisons, the leukocyte reduction was not associated with culture-proven postoperative infections and 90-day mortality. CONCLUSION: No beneficial effect of the universal leukocyte reduction in cardiac surgery was found for culture-positive infection rates, 90-day mortality, or length of intensive care stay. |
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Authors:
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Leena Capraro; Anne Kuitunen; Antti E Vento; Raili Suojaranta-Ylinen; Elina Kolho; Ville Pettilä |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2006-12-22 |
Journal Detail:
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Title: Journal of cardiothoracic and vascular anesthesia Volume: 21 ISSN: 1053-0770 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-09 Completed Date: 2007-07-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: United States |
Other Details:
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Languages: eng Pagination: 232-6 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bacteremia / epidemiology, etiology Cardiac Surgical Procedures* / mortality Erythrocyte Transfusion* / adverse effects Female Finland Heart Diseases / surgery Humans Intensive Care Units Length of Stay / statistics & numerical data Leukocyte Reduction Procedures* Logistic Models Male Mediastinitis / epidemiology, etiology Middle Aged Multivariate Analysis Pneumonia / epidemiology, etiology Research Design Retrospective Studies Surgical Wound Infection / epidemiology, etiology Survival Analysis Treatment Failure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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