| Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms. | |
| | |
MedLine Citation:
|
PMID: 21942366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The topipotency of the germline is the full manifestation of the pluri- and multipotency of embryonic and adult stem cells, thus the germline and stem cells must share common mechanisms that guarantee their multipotentials in development. One of the few such known shared mechanisms is represented by Piwi proteins, which constitute one of the two subfamilies of the Argonaute protein family. Piwi proteins bind to Piwi-interacting RNAs (piRNAs) that are generally 26 to 31 nucleotides in length. Both Piwi proteins and piRNAs are most abundantly expressed in the germline. Moreover, Piwi proteins are expressed broadly in certain types of somatic stem/progenitor cells and other somatic cells across animal phylogeny. Recent studies indicate that the Piwi-piRNA pathway mediates epigenetic programming and posttranscriptional regulation, which may be responsible for its function in germline specification, gametogenesis, stem cell maintenance, transposon silencing, and genome integrity in diverse organisms. |
| | |
Authors:
|
Celina Juliano; Jianquan Wang; Haifan Lin |
Related Documents
:
|
20554796 - Identification of bracovirus particle proteins and analysis of their transcript levels ... 21366716 - Comparative proteomic analysis of follicular fluids from normal and cystic follicles in... 21741246 - Cdc48: a power machine in protein degradation. 21403916 - Identification of specific interaction of juvenile hormone binding protein with isocitr... 8844476 - Protein-restricted diet alters concentration of plasma membrane glycoproteins in rat li... 8882496 - Regionally regulated conversion of protein expression in the skin during anuran metamor... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-09-19 |
Journal Detail:
|
Title: Annual review of genetics Volume: 45 ISSN: 1545-2948 ISO Abbreviation: Annu. Rev. Genet. Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-11-08 Completed Date: 2012-02-24 Revised Date: 2013-06-03 |
Medline Journal Info:
|
Nlm Unique ID: 0117605 Medline TA: Annu Rev Genet Country: United States |
Other Details:
|
Languages: eng Pagination: 447-69 Citation Subset: IM |
Affiliation:
|
Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06509, USA. haifan.lin@yale.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Argonaute Proteins / genetics, metabolism* DNA Transposable Elements Drosophila / cytology, genetics, metabolism, physiology Epigenesis, Genetic Evolution, Molecular Germ Cells / cytology, metabolism, physiology* Humans Protein Biosynthesis Protein Interaction Domains and Motifs RNA Processing, Post-Transcriptional RNA, Messenger / genetics, metabolism RNA, Small Interfering / genetics, metabolism* Repressor Proteins / genetics, metabolism Reproduction Stem Cells / cytology, metabolism, physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
DP1 CA174418/CA/NCI NIH HHS; DP1OD006852/OD/NIH HHS; F32GM090372/GM/NIGMS NIH HHS; R01HD37760S1/HD/NICHD NIH HHS; R01HD42042/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Argonaute Proteins; 0/DNA Transposable Elements; 0/PIWIL1 protein, human; 0/RNA, Messenger; 0/RNA, Small Interfering; 0/Repressor Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genomic Analysis at the Single-Cell Level.
Next Document: Maternal and Zygotic Control of Zebrafish Dorsoventral Axial Patterning.