Document Detail


Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms.
MedLine Citation:
PMID:  21942366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The topipotency of the germline is the full manifestation of the pluri- and multipotency of embryonic and adult stem cells, thus the germline and stem cells must share common mechanisms that guarantee their multipotentials in development. One of the few such known shared mechanisms is represented by Piwi proteins, which constitute one of the two subfamilies of the Argonaute protein family. Piwi proteins bind to Piwi-interacting RNAs (piRNAs) that are generally 26 to 31 nucleotides in length. Both Piwi proteins and piRNAs are most abundantly expressed in the germline. Moreover, Piwi proteins are expressed broadly in certain types of somatic stem/progenitor cells and other somatic cells across animal phylogeny. Recent studies indicate that the Piwi-piRNA pathway mediates epigenetic programming and posttranscriptional regulation, which may be responsible for its function in germline specification, gametogenesis, stem cell maintenance, transposon silencing, and genome integrity in diverse organisms.
Authors:
Celina Juliano; Jianquan Wang; Haifan Lin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-09-19
Journal Detail:
Title:  Annual review of genetics     Volume:  45     ISSN:  1545-2948     ISO Abbreviation:  Annu. Rev. Genet.     Publication Date:  2011  
Date Detail:
Created Date:  2011-11-08     Completed Date:  2012-02-24     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  0117605     Medline TA:  Annu Rev Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-69     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Argonaute Proteins / genetics,  metabolism*
DNA Transposable Elements
Drosophila / cytology,  genetics,  metabolism,  physiology
Epigenesis, Genetic
Evolution, Molecular
Germ Cells / cytology,  metabolism,  physiology*
Humans
Protein Biosynthesis
Protein Interaction Domains and Motifs
RNA Processing, Post-Transcriptional
RNA, Messenger / genetics,  metabolism
RNA, Small Interfering / genetics,  metabolism*
Repressor Proteins / genetics,  metabolism
Reproduction
Stem Cells / cytology,  metabolism,  physiology*
Grant Support
ID/Acronym/Agency:
DP1 CA174418/CA/NCI NIH HHS; DP1 OD006825/OD/NIH HHS; DP1OD006852/OD/NIH HHS; F32GM090372/GM/NIGMS NIH HHS; R01 HD033760/HD/NICHD NIH HHS; R01 HD042012/HD/NICHD NIH HHS; R01HD37760S1/HD/NICHD NIH HHS; R01HD42042/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Argonaute Proteins; 0/DNA Transposable Elements; 0/PIWIL1 protein, human; 0/RNA, Messenger; 0/RNA, Small Interfering; 0/Repressor Proteins
Comments/Corrections

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