| Unique promotion of erythrophagocytosis by malondialdehyde. | |
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MedLine Citation:
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PMID: 3189319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Modification of the normal erythrocyte membrane by reagent malondialdehyde (MDA) promotes phagocytosis of red blood cells by human macrophages, a phenomenon previously shown to involve both IgG-dependent and IgG-independent mechanisms and to be demonstrable even at micromolar MDA concentrations. In the present studies, we demonstrate this effect using 1mM MDA prepared both by acid hydrolysis of malonaldehyde bis-(dimethyl acetal) and by enzymatic synthesis from 1,3-propanediol. Remarkably, we find that equimolar amounts of other mono- and dialdehydes fail to promote erythrophagocytosis despite similarity to MDA in size and structure and ability to cross link. Authentic MDA seems to be unique among small aldehydes in ability to promote erythrophagocytosis at low aldehyde concentration and, therefore, has a special biologic relevance among the great variety of peroxidation byproducts. |
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Authors:
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R P Hebbel; W J Miller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of hematology Volume: 29 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1988-12-21 Completed Date: 1988-12-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 222-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Minnesota, Minneapolis. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldehydes
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pharmacology Chemical Phenomena Chemistry Erythrocytes / drug effects* Humans Hydrogen Peroxide / pharmacology Macrophages / physiology* Malonates / pharmacology* Malondialdehyde / chemical synthesis, pharmacology* Phagocytosis / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL01130/HL/NHLBI NIH HHS; HL30160/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Malonates; 542-78-9/Malondialdehyde; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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