Document Detail

Unique promotion of erythrophagocytosis by malondialdehyde.
MedLine Citation:
PMID:  3189319     Owner:  NLM     Status:  MEDLINE    
Modification of the normal erythrocyte membrane by reagent malondialdehyde (MDA) promotes phagocytosis of red blood cells by human macrophages, a phenomenon previously shown to involve both IgG-dependent and IgG-independent mechanisms and to be demonstrable even at micromolar MDA concentrations. In the present studies, we demonstrate this effect using 1mM MDA prepared both by acid hydrolysis of malonaldehyde bis-(dimethyl acetal) and by enzymatic synthesis from 1,3-propanediol. Remarkably, we find that equimolar amounts of other mono- and dialdehydes fail to promote erythrophagocytosis despite similarity to MDA in size and structure and ability to cross link. Authentic MDA seems to be unique among small aldehydes in ability to promote erythrophagocytosis at low aldehyde concentration and, therefore, has a special biologic relevance among the great variety of peroxidation byproducts.
R P Hebbel; W J Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hematology     Volume:  29     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1988-12-21     Completed Date:  1988-12-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  222-5     Citation Subset:  IM    
Department of Medicine, University of Minnesota, Minneapolis.
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MeSH Terms
Aldehydes / pharmacology
Chemical Phenomena
Erythrocytes / drug effects*
Hydrogen Peroxide / pharmacology
Macrophages / physiology*
Malonates / pharmacology*
Malondialdehyde / chemical synthesis,  pharmacology*
Phagocytosis / drug effects*
Grant Support
Reg. No./Substance:
0/Aldehydes; 0/Malonates; 542-78-9/Malondialdehyde; 7722-84-1/Hydrogen Peroxide

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