Document Detail


Unique promotion of erythrophagocytosis by malondialdehyde.
MedLine Citation:
PMID:  3189319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Modification of the normal erythrocyte membrane by reagent malondialdehyde (MDA) promotes phagocytosis of red blood cells by human macrophages, a phenomenon previously shown to involve both IgG-dependent and IgG-independent mechanisms and to be demonstrable even at micromolar MDA concentrations. In the present studies, we demonstrate this effect using 1mM MDA prepared both by acid hydrolysis of malonaldehyde bis-(dimethyl acetal) and by enzymatic synthesis from 1,3-propanediol. Remarkably, we find that equimolar amounts of other mono- and dialdehydes fail to promote erythrophagocytosis despite similarity to MDA in size and structure and ability to cross link. Authentic MDA seems to be unique among small aldehydes in ability to promote erythrophagocytosis at low aldehyde concentration and, therefore, has a special biologic relevance among the great variety of peroxidation byproducts.
Authors:
R P Hebbel; W J Miller
Related Documents :
16416459 - Ethically justified clinical strategies for promoting geriatric assent.
11565449 - Methods of the national check bus project.
3957779 - A paying health promotion clinic: combining client services and student learning.
10276149 - Strategies for promoting the health of minorities: the school-age population.
23941189 - Occupational therapists in rural healthcare: a "jack of all trades".
7119609 - Medicine as patriarchal religion.
11141669 - Diversity among hospice volunteers: a challenge for the development of a responsive vol...
15900419 - Refugees' perceptions of healthy behaviors.
2520009 - Mechanical factors in the degeneration of porcine bioprosthetic valves: an overview.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hematology     Volume:  29     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1988-12-21     Completed Date:  1988-12-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  222-5     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Minnesota, Minneapolis.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aldehydes / pharmacology
Chemical Phenomena
Chemistry
Erythrocytes / drug effects*
Humans
Hydrogen Peroxide / pharmacology
Macrophages / physiology*
Malonates / pharmacology*
Malondialdehyde / chemical synthesis,  pharmacology*
Phagocytosis / drug effects*
Grant Support
ID/Acronym/Agency:
HL01130/HL/NHLBI NIH HHS; HL30160/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Aldehydes; 0/Malonates; 542-78-9/Malondialdehyde; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Extensive bone marrow necrosis in patients with cancer and tumor necrosis factor activity in plasma.
Next Document:  Familial type II protein C deficiency associated with warfarin-induced skin necrosis and bilateral a...