Document Detail


Unique presentations of epidermal growth factor receptor inhibitor-induced papulopustular eruption related to bacterial superinfection.
MedLine Citation:
PMID:  23552005     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Epidermal growth factor receptor (EGFR) inhibitors have been reported to induce numerous cutaneous side effects, the most notable of which is a papulopustular eruption on the face, scalp, and central chest. The typical presentation consists of inflamed papules, often with pustules, favoring a seborrheic distribution. The pustules of the EGFR inhibitor-induced papulopustular eruption are commonly sterile but bacterial superinfection is not uncommon. We report two unique presentations of the papulopustular eruption that were found to be associated with Staphylococcus aureus superinfection. One patient presented with an abrupt onset of nearly confluent red plaques on the cheeks, forehead, chin, and neck, with innumerable studded pinpoint pustules. The other patient had a long-standing untreated papulopustular eruption on the scalp, which resulted in widespread erythema, large thick plaques of serous crust, pustular exudate, and associated alopecia. Both patients quickly resolved with non-tetracycline oral antibiotics combined with topical steroid treatment.
Authors:
Lauren Elyse Wiznia; Jennifer Nam Choi
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Publication Detail:
Type:  Journal Article     Date:  2013-03-15
Journal Detail:
Title:  Dermatology online journal     Volume:  19     ISSN:  1087-2108     ISO Abbreviation:  Dermatol. Online J.     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610776     Medline TA:  Dermatol Online J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8     Citation Subset:  IM    
Affiliation:
Yale University School of Medicine, New Haven, Connecticut.
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