| Unique patient issues: early interventions and management. | |
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MedLine Citation:
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PMID: 22585636 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Patient cases that present with recurring fertilization failure or complete abnormality in either the oocytes or sperm before fertilization are uncommon, yet they are devastating. This review presents several such instances, including oocyte maturation blocks, empty follicle syndrome, oocyte activation failures, defects in sperm phospholipase C isoform ζ, sperm structural anomalies, spontaneous oocyte activation, and unexplained cases. Diagnostic efforts have not only provided insight into possible etiologies but also have helped manage such challenging cases. Interventions may comprise cellular, molecular, or genetic analyses of gametes, as well as functional assays and/or modified treatment strategies. Consequently, infertility professionals can increasingly rely on evidence-based counseling with respect to prognosis and treatment options. |
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Authors:
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Catherine Combelles |
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Publication Detail:
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Type: Journal Article Date: 2012-05-14 |
Journal Detail:
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Title: Seminars in reproductive medicine Volume: 30 ISSN: 1526-4564 ISO Abbreviation: Semin. Reprod. Med. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100909394 Medline TA: Semin Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 243-52 Citation Subset: IM |
Copyright Information:
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Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. |
Affiliation:
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Department of Biology, Middlebury College, Middlebury, Vermont. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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