Document Detail


Unique coronary vasodilator induction by leukotriene D4.
MedLine Citation:
PMID:  4037115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Coronary blood flow (CBF) and myocardial contractility decrease markedly in response to intracoronary administration of leukotriene D4 (LTD4). With steady infusion, however, both CBF and contractility escape, approaching preinfusion values despite ongoing LTD4 administration. To clarify the mechanism of this escape, we reinfused plasma from the coronary vein draining the myocardial area receiving LTD4. Introducing this plasma into a coronary artery caused a marked rise in coronary flow for the duration of the plasma infusion. Coronary flow reduction with vasopressin or mechanical occlusion matching that caused by LTD4 failed to elicit vasodilator production. Thus a unique coronary vasodilator factor is induced by LTD4. Whole blood or platelet-rich plasma incubated with LTD4 in vitro produced the same pattern of coronary dilation on intracoronary infusion; LTD4 incubation with platelet-poor plasma failed to elicit a vasodilation. The vasodilator factor is stable and is not potassium, a prostaglandin, catecholamine, histamine, serotonin, adenosine, adenosine diphosphate, or platelet-activating factor. Production of this leukotriene-induced vasodilator factor may account for the escape from LTD4-induced coronary constriction.
Authors:
D Ezra; G Feuerstein; J F Czaja; F R Laurindo; C K Finton; G C Yeh; R E Goldstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  249     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-10-10     Completed Date:  1985-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H698-702     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine / pharmacology
Animals
Blood Platelets / physiology
Blood Pressure / drug effects
Coronary Circulation / drug effects*
Heart / drug effects,  physiology*
Heart Rate / drug effects
Kinetics
Myocardial Contraction / drug effects*
SRS-A / pharmacology*
Swine
Time Factors
Vasodilation / drug effects*
Chemical
Reg. No./Substance:
0/SRS-A; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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