Document Detail

Elsevier Trophoblast Research Award Lecture: Unique properties of decidual T cells and their role in immune regulation during human pregnancy.
MedLine Citation:
PMID:  20106522     Owner:  NLM     Status:  MEDLINE    
Maternal lymphocytes at the fetal-maternal interface play a key role in the immune acceptance of the allogeneic fetus. Most studies focus on decidual NK cells and their interaction with fetal trophoblasts, whereas limited data are available on the mechanisms of fetus specific immune recognition and immune regulation by decidual T cells at the fetal-maternal interface. The aim of this review is to describe the phenotypic characteristics of decidual T cell subsets present at the fetal-maternal interface, their interaction with HLA-C expressed by fetal trophoblasts and their role in immune recognition and regulation at the fetal-maternal interface during human pregnancy.
T Tilburgs; F H J Claas; S A Scherjon
Publication Detail:
Type:  Lectures     Date:  2010-01-27
Journal Detail:
Title:  Placenta     Volume:  31 Suppl     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  S82-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
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MeSH Terms
Decidua / immunology*
HLA-C Antigens / immunology
Maternal-Fetal Exchange / immunology
T-Lymphocytes / immunology*
Reg. No./Substance:
0/HLA-C Antigens

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