| A Unique Manifestation of Pupillary Fatigue in Autoimmune Autonomic Ganglionopathy. | |
| | |
MedLine Citation:
|
PMID: 22232207 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To demonstrate a unique abnormality of the pupillary light reflex in patients with autoimmune autonomic ganglionopathy (AAG). DESIGN: Case series. SETTING: Autonomic clinics at 2 university hospitals (University of Texas Southwestern Medical Center and Beth Israel Deaconess Medical Center). PARTICIPANTS: Seven patients with antibody-positive AAG. INTERVENTIONS: All patients with AAG underwent either monocular or binocular infrared pupillometry using a standard 2-second light stimulus at a defined intensity. Findings were compared with those from healthy control subjects and patients with other autonomic disorders. The light stimulus used in this study was selected to eliminate the normal phenomenon of pupil escape. MAIN OUTCOME MEASURES: The time to onset of redilation as well as other indices of pupillary constriction to light stimulus. RESULTS: Patients with AAG exhibited premature pupillary redilation (mean [SD], 1.02 [0.20] seconds) compared with healthy control subjects (mean [SD], 2.24 [0.10] seconds) and other patients with autonomic disorders (mean [SD], 2.30 [0.12] seconds) (P < .001). In healthy control subjects and patients with other autonomic disorders, pupillary redilation always followed the termination of the light stimulus; in patients with AAG, redilation consistently occurred during the light stimulus. In 1 patient, serial repetitive light stimulation further decreased the time to onset of redilation. CONCLUSIONS: Premature redilation of the pupil is a unique physiological feature seen only in patients with AAG. This phenomenon appears to be a manifestation of pupillary fatigue, a clinical correlate of defective synaptic transmission at the level of autonomic ganglia in antibody-positive AAG. |
| | |
Authors:
|
Srikanth Muppidi; Maggie Scribner; Christopher H Gibbons; Beverley Adams-Huet; Elaine B Spaeth; Steven Vernino |
Related Documents
:
|
20463867 - Object repetition leads to local increases in the temporal coordination of neural respo... 3168717 - Effect of adaptation and wavelength on the power spectrum of human oscillatory potentials. 9104827 - Magnetoencephalographic recording of steady-state visual evoked cortical activity. 21972177 - Fish out of water: terrestrial jumping by fully aquatic fishes. 7662697 - Electric parameters of na+/k(+)-atpase by measurements of the fluorescence-detected ele... 21161357 - Non-linear stimulus-response behavior of the human stance control system is predicted b... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-9 |
Journal Detail:
|
Title: Archives of neurology Volume: - ISSN: 1538-3687 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University of Texas Southwestern Medical Center, Dallas; and Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (Dr Gibbons). |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition.
Next Document: The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic ur...