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A Unique Case of Malignant Pleuropericardial Effusion: HHV-8-Unrelated PEL-Like Lymphoma-A Case Report and Review of the Literature.
MedLine Citation:
PMID:  24716045     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Primary effusion lymphoma (PEL) or body cavity lymphoma is a rare type of extra nodal lymphoma of B-cell origin that presents as lymphomatous effusion(s) without any nodal enlargement or tumor masses. It belongs to the group of AIDS related non-Hodgkin's lymphomas. First described in 1996 in HIV infected individuals who were coinfected with Kaposi's sarcoma-associated herpesvirus (KSHV) or HHV-8 virus, it was included as a separate entity in WHO classification of tumors of hematopoietic and lymphoid tissue in the year 2001. The definition included association with HHV-8 virus as a mandatory diagnostic criterion. However, cases were later reported where PEL-like disease process was diagnosed in HHV-8 negative patients. This was eventually recognized as a rare but distinct entity termed as "HHV-8-unrelated PEL-like lymphoma". Herein, we are reporting a case of an elderly patient who presented with a large pleuropericardial effusion and was eventually diagnosed with this entity. Till date, only around 50 cases of HHV-8-unrelated PEL-like lymphoma have been reported and our case being EBV, HIV, and Hepatitis C negative makes it very unique and rare occurrence. We are also presenting a review of relevant literature focused mainly on comparing outcomes in patients treated with and without chemotherapy.
Authors:
Farhan Mohammad; Muhammad Neaman Siddique; Faraz Siddiqui; M Popalzai; Masoud Asgari; Marcel Odaimi
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Publication Detail:
Type:  Journal Article     Date:  2014-03-04
Journal Detail:
Title:  Case reports in oncological medicine     Volume:  2014     ISSN:  2090-6706     ISO Abbreviation:  Case Rep Oncol Med     Publication Date:  2014  
Date Detail:
Created Date:  2014-04-09     Completed Date:  2014-04-09     Revised Date:  2014-04-11    
Medline Journal Info:
Nlm Unique ID:  101581035     Medline TA:  Case Rep Oncol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  436821     Citation Subset:  -    
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