| Unintentional fatal paraquat poisonings among agricultural workers in Costa Rica: report of 15 cases. | |
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MedLine Citation:
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PMID: 9327065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study analyzes the exposure circumstances of 15 fatal occupational paraquat poisonings. To evaluate the potential danger of dermal absorption and the amount needed to produce a fatal outcome in the event of oral intake, we reviewed the medical records and autopsy protocols and interviewed relatives. Five fatalities were due to ingestion of a mouthful of paraquat concentrate, and five to intake of a smaller amount; three cases were associated with dermal exposure, and in two, there was no evidence of either oral or dermal exposure. Several cases concerned diluted paraquat spray. The clinical and pathomorphological findings, including a "blinded" evaluation of lung slides, were consistent with paraquat poisoning in all cases. Difficulties in establishing the diagnosis and recognizing the exposure were identified, as well as classification of unintentional poisonings as suicides at autopsy. The findings suggest that paraquat may cause fatal poisonings by ingestion of small amounts, by dermal absorption of diluted paraquat, and possibly by inhalation. More conclusive studies are warranted. |
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Authors:
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C Wesseling; C Hogstedt; A Picado; L Johansson |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of industrial medicine Volume: 32 ISSN: 0271-3586 ISO Abbreviation: Am. J. Ind. Med. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1997-11-14 Completed Date: 1997-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8101110 Medline TA: Am J Ind Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 433-41 Citation Subset: IM |
Affiliation:
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Pesticide Program, Universidad Nacional, Heredia, Costa Rica, catharina.wesseling@imm.ki.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adolescent Adult Aged Agricultural Workers' Diseases / epidemiology* Child Costa Rica / epidemiology Diagnosis, Differential Dose-Response Relationship, Drug Herbicides / poisoning* Humans Inhalation Exposure Male Middle Aged Occupational Exposure / adverse effects*, prevention & control Paraquat / poisoning* Poisoning / diagnosis, mortality Pulmonary Edema / chemically induced, mortality Respiratory Distress Syndrome, Adult / chemically induced, mortality Retrospective Studies Skin Absorption / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Herbicides; 4685-14-7/Paraquat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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