Document Detail


Unintentional fatal paraquat poisonings among agricultural workers in Costa Rica: report of 15 cases.
MedLine Citation:
PMID:  9327065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study analyzes the exposure circumstances of 15 fatal occupational paraquat poisonings. To evaluate the potential danger of dermal absorption and the amount needed to produce a fatal outcome in the event of oral intake, we reviewed the medical records and autopsy protocols and interviewed relatives. Five fatalities were due to ingestion of a mouthful of paraquat concentrate, and five to intake of a smaller amount; three cases were associated with dermal exposure, and in two, there was no evidence of either oral or dermal exposure. Several cases concerned diluted paraquat spray. The clinical and pathomorphological findings, including a "blinded" evaluation of lung slides, were consistent with paraquat poisoning in all cases. Difficulties in establishing the diagnosis and recognizing the exposure were identified, as well as classification of unintentional poisonings as suicides at autopsy. The findings suggest that paraquat may cause fatal poisonings by ingestion of small amounts, by dermal absorption of diluted paraquat, and possibly by inhalation. More conclusive studies are warranted.
Authors:
C Wesseling; C Hogstedt; A Picado; L Johansson
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  32     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-11-14     Completed Date:  1997-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  433-41     Citation Subset:  IM    
Affiliation:
Pesticide Program, Universidad Nacional, Heredia, Costa Rica, catharina.wesseling@imm.ki.se
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adolescent
Adult
Aged
Agricultural Workers' Diseases / epidemiology*
Child
Costa Rica / epidemiology
Diagnosis, Differential
Dose-Response Relationship, Drug
Herbicides / poisoning*
Humans
Inhalation Exposure
Male
Middle Aged
Occupational Exposure / adverse effects*,  prevention & control
Paraquat / poisoning*
Poisoning / diagnosis,  mortality
Pulmonary Edema / chemically induced,  mortality
Respiratory Distress Syndrome, Adult / chemically induced,  mortality
Retrospective Studies
Skin Absorption / drug effects
Chemical
Reg. No./Substance:
0/Herbicides; 4685-14-7/Paraquat

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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