| Unintended effects of cranial irradiation on cognitive function. | |
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MedLine Citation:
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PMID: 19880825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review summarizes some of the topics discussed at the 28th Annual Symposium of the Society of Toxicologic Pathology. The symposium was held in Washington, DC, in 2009 and dealt with unintended adverse events associated with cranial irradiation as part of cancer therapy. We will discuss the importance of considering genetic susceptibility and sex differences in susceptibility to develop these adverse events. Further, we will discuss potential mechanisms contributing to these events, including alterations in neurogenesis and increased oxidative stress following irradiation and potential alterations in synaptic and dendritic markers. |
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Authors:
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Jacob Raber |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2009-10-30 |
Journal Detail:
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Title: Toxicologic pathology Volume: 38 ISSN: 1533-1601 ISO Abbreviation: Toxicol Pathol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-23 Completed Date: 2010-05-11 Revised Date: 2012-01-05 |
Medline Journal Info:
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Nlm Unique ID: 7905907 Medline TA: Toxicol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 198-202 Citation Subset: IM |
Affiliation:
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Department of Behavioral Neuroscience, and Division of Neuroscience, ONPRC, Oregon Health and Science University, Portland, Oregon 97239, USA. raberj@ohsu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / adverse effects Cognition / radiation effects* Cranial Irradiation / adverse effects* Female Genetic Predisposition to Disease Humans Male Mice Neurogenesis Oxidative Stress Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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