Document Detail


Unilateral vs. bilateral retinoblastoma. Correlations between age at diagnosis and stage of ocular disease.
MedLine Citation:
PMID:  3763146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Retrospective analysis of 358 cases of retinoblastoma for correlation between age and intraocular stage at the time of diagnosis revealed: in both early and advanced stages of intraocular disease, bilateral retinoblastoma presents at an earlier age than does unilateral retinoblastoma; support for the Knudson "two-hit" hypothesis of retinoblastoma genetics, the existence of a positive family history for retinoblastoma does not guarantee an earlier age at diagnosis compared to sporadic disease; and for any age at diagnosis, unilateral or bilateral disease, Group V is the most common intraocular stage found.
Authors:
M Rubenfeld; D H Abramson; R M Ellsworth; F D Kitchin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmology     Volume:  93     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-11-14     Completed Date:  1986-11-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1016-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Eye Neoplasms / pathology*,  physiopathology
Humans
Neoplasm Staging
Retinoblastoma / pathology*,  physiopathology
Retrospective Studies

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