Document Detail

Unilateral vestibular loss due to systemically administered gentamicin.
MedLine Citation:
PMID:  21844784     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: : To report the little known fact that systemically administered gentamicin can cause severe unilateral, rather than only bilateral vestibular loss.
METHODS: : This is a retrospective review of patients presenting with imbalance and oscillopsia due to a compensated, selective unilateral vestibular loss, who denied ever experiencing vertigo, but who had been administered systemic gentamicin during a hospital admission just before their symptoms began.
RESULTS: : From 1993 to 2011, 18 such patients were identified from the records of our tertiary referral Balance Disorders Clinic. The fact that they had been administered gentamicin was confirmed only when the hospital charts were examined. Only 4 of 18 patients knew or suspected that they had been administered gentamicin; none had been administered gentamicin at the authors' hospital.
CONCLUSION: : These results mean that any patient presenting with imbalance due to a compensated, selective unilateral vestibular loss, who has never experienced vertigo, should be closely questioned about any hospital admission just before symptoms started and the hospital records for that admission requisitioned and scrutinized for possible gentamicin therapy.
Rebekah M Ahmed; Hamish G Macdougall; G Michael Halmagyi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology     Volume:  32     ISSN:  1537-4505     ISO Abbreviation:  Otol. Neurotol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100961504     Medline TA:  Otol Neurotol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1158-62     Citation Subset:  IM    
*Neurology Department, Royal Prince Alfred Hospital, Sydney; †Vestibular Research Laboratory, School of Psychology, University of Sydney, Sydney, New South Wales, Australia.
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