Document Detail

Unilateral uterine ischemia/reperfusion-induced bilateral fetal loss and fetal growth restriction in a murine model require intact complement component 5.
MedLine Citation:
PMID:  22688254     Owner:  NLM     Status:  MEDLINE    
The role of complement in ischemia/reperfusion-induced fetal growth restriction and fetal loss is unknown. C5-deficient or wild type timed-pregnant mice were subjected to unilateral uterine ischemia/reperfusion on gestation day 13, either by (1) partial flow restriction by right ovarian artery clamping for 30 min, or (2) total flow restriction by clamping both ovarian and uterine arteries for 5 min. Ischemia/reperfusion-challenged pregnancy outcomes were compared to sham-operated controls 5 days later. Ischemia/reperfusion-treated wild type mice exhibited significantly increased bilateral fetal loss, which was greater in total flow restriction than in partial flow restriction, and decreased fetal weights, which were the same in total flow restriction and partial flow restriction for the surviving fetuses. Placental weights were unchanged by treatments. Ischemia/reperfusion increased uterine, but not placental, myeloperoxidase activity, which correlated with fetal loss. In contrast, C5-deficient mice were protected from both fetal growth restriction and fetal loss, and exhibited no increase in myeloperoxidase activity. These results demonstrate that unilateral uterine ischemia/reperfusion results in bilateral fetal loss and fetal growth restriction, mediated by a systemic mechanism. In the current model, this pathological process is completely dependent on intact complement component 5.
Xiao-Wu Qu; Tamas Jilling; Mark G Neerhof; Kehuan Luo; Emmet Hirsch; Larry G Thaete
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-09
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  95     ISSN:  1872-7603     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-03     Completed Date:  2013-01-15     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  27-35     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Department of Obstetrics & Gynecology, NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA.
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MeSH Terms
Complement C5 / genetics,  immunology*,  metabolism
Disease Models, Animal
Enzyme Activation
Fetal Death / genetics,  immunology*,  metabolism,  pathology
Fetal Growth Retardation / genetics,  immunology*,  metabolism,  pathology
Mice, Mutant Strains
Peroxidase / genetics,  immunology,  metabolism
Placenta / blood supply,  immunology*,  metabolism,  pathology
Reperfusion Injury / genetics,  immunology*,  metabolism,  pathology
Uterus / blood supply,  immunology*,  metabolism,  pathology
Grant Support
Reg. No./Substance:
0/Complement C5; EC

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