| Unilateral renal artery stenosis seen initially as severe and symptomatic hypokalemia. Pathophysiologic assessment and effects of surgical revascularization. | |
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MedLine Citation:
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PMID: 8442694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypokalemia is an uncommon presentation of renovascular hypertension. Although renal artery stenosis has been associated with hypokalemia secondary to hyperreninemic hyperaldosteronism, few reports have actually evaluated the pathophysiologic changes in such a patient with renovascular hypertension. We studied a patient before and after surgical revascularization who presented with severe hypertension and marked, symptomatic hypokalemia. Before surgery, the patient had excessive urinary potassium secretion, markedly increased secretion of renin after captopril stimulation, and mild secondary hyperaldosteronism. Postoperatively, the patient's blood pressure decreased moderately and the serum and urinary potassium values normalized. After revascularization, plasma renin activity both before and after captopril stimulation and serum aldosterone levels decreased markedly. These findings demonstrate that renovascular hypertension may rarely present with symptomatic hypokalemia secondary to excessive aldosterone secretion. Improvement in the renal ischemic state is accompanied by rapid correction of the metabolic disturbances associated with hyperreninemic hyperaldosteronism. |
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Authors:
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S T Ruby; A Burch; W B White |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 128 ISSN: 0004-0010 ISO Abbreviation: Arch Surg Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-03-29 Completed Date: 1993-03-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 346-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Connecticut School of Medicine, Farmington. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood Diagnosis, Differential Humans Hyperaldosteronism / blood, physiopathology Hypertension, Renovascular / diagnosis, physiopathology, surgery Hypokalemia / diagnosis*, physiopathology Male Middle Aged Potassium / blood, urine Renal Artery / surgery Renal Artery Obstruction / diagnosis*, physiopathology, surgery Renin / blood Splenic Artery / surgery |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; 7440-09-7/Potassium; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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