| Unilateral pudendal nerve blockade for relief of all pain during transrectal ultrasound-guided biopsy of the prostate: a randomized, double-blind, placebo-controlled study. | |
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MedLine Citation:
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PMID: 15351584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate the efficacy of unilateral pudendal nerve block for the relief of all pain during transrectal ultrasound (TRUS)-guided prostate biopsy. TRUS-guided prostate biopsy is the standard procedure to diagnose or rule out prostate cancer. The pain, attributed to ultrasound probe insertion and the needle punctures into the prostate, inflicted by TRUS-guided prostate biopsy limits its effectiveness. METHODS: We performed a prospective, randomized, double-blind, placebo-controlled study of 65 consecutive men suspected of having prostate cancer who were undergoing TRUS-guided prostate biopsy, 51 of whom fulfilled the inclusion criteria. Before the biopsy, each patient was randomized to one of two groups. Both the patient and the physician who performed the TRUS-guided biopsy were unaware of the contents of the injection for the pudendal nerve block. Unilateral pudendal nerve blockade was performed transperineally with digital rectal examination guidance using 10 mg of 1% prilocaine (group 1 [n = 26]) or 10 mL of a 0.9 NaCl solution (group 2 [n = 25]) by way of a 22-gauge spinal needle by the same anesthetist. Pain was evaluated using an 11-point visual analog scale questionnaire. RESULTS: No statistically significant differences were found in the visual analog scale score for pain during the pudendal nerve blockade or digital rectal examination between the groups. A statistically significant difference was found in the visual analog scale score for the biopsy procedure (P < 0.01) and probe discomfort (P < 0.05) between the two groups. CONCLUSIONS: Unilateral pudendal nerve blockade was effective in reducing the pain at both biopsy and probe manipulation in our study. |
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Authors:
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Oztuğ Adsan; Gürdal Inal; Levent Ozdoğan; Onur Kaygisiz; Ozgür Uğurlu; Mesut Cetinkaya |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Urology Volume: 64 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-07 Completed Date: 2005-04-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: United States |
Other Details:
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Languages: eng Pagination: 528-31 Citation Subset: IM |
Affiliation:
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Department of Urology, Ankara Numune Education and Research Hospital, Ankara, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anesthetics, Local / administration & dosage Autonomic Nerve Block / methods* Biopsy, Needle / adverse effects, methods* Double-Blind Method Humans Male Middle Aged Pain / etiology, prevention & control* Pain Measurement Prilocaine / administration & dosage Prospective Studies Prostate / innervation, pathology* Prostatic Neoplasms / diagnosis* Ultrasonography, Interventional |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 721-50-6/Prilocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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