Document Detail

Unilateral papilloedema after hepatitis B vaccination in a migraine patient. A case report including forensic aspects.
MedLine Citation:
PMID:  10634574     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report on a unilateral optic nerve reaction appearing 9-10 hours after vaccination against hepatitis B. METHODS: To describe the case and discuss the underlying mechanisms. There was a scintillating scotoma leaving a permanent inferior notch in the visual field, but central vision was left normal and with only a slight affection of colour perception. Shortly the optic nervehead appeared engorged, then slightly ischaemic, but was hardly left with evidence of atrophy. RESULTS: Immune-based reactions could hardly be held responsible, multiple sclerosis was unlikely, and ultrasonography excluded optic nervehead drusen. An optic nerve migraine mechanism is probable, possibly with the vaccination having acted as the trigger.
H C Fledelius
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta ophthalmologica Scandinavica     Volume:  77     ISSN:  1395-3907     ISO Abbreviation:  Acta Ophthalmol Scand     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  9507578     Medline TA:  Acta Ophthalmol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  722-4     Citation Subset:  IM    
University Eye Department, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Color Perception / drug effects
Fluorescein Angiography
Fundus Oculi
Hepatitis B / prevention & control*
Hepatitis B Vaccines / adverse effects*
Middle Aged
Migraine Disorders / complications*
Optic Disk / drug effects,  pathology
Papilledema / chemically induced*,  complications,  diagnosis
Vaccination / adverse effects*
Visual Acuity / drug effects
Reg. No./Substance:
0/Hepatitis B Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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