Document Detail

Unilateral kidney blood flow measurement using the 81Rb/81mKr ratio.
MedLine Citation:
PMID:  699597     Owner:  NLM     Status:  MEDLINE    
A new method has been developed for the continuous quantification of kidney blood flow, utilizing the unique physical and biological properties of the radioactive tracer couple: rubidium-81/krypton-81m. After intravenous injection, 81Rb concentrates primarily in the kidneys, where it continuously generates the radioactive inert gas 81mKr. This ultrashort-lived isotope is continuously washed out from the tissue at a rate proportional to the blood flow. The radiation emitted from within the kidney is externally detected and analyzed to yield the 81Rb/81mKr ratio. 21 animal experiments have confirmed that this ratio is at any time an accurate measure of the kidney perfusion. The 81Rb/81mKr ratio method has proved to provide a non-invasive way to selectively quantify the blood flow in each kidney, to monitor perfusion changes and to image the distribution of blood flow in a functional scintigram.
G van Herk; D de Zeeuw
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contributions to nephrology     Volume:  11     ISSN:  0302-5144     ISO Abbreviation:  Contrib Nephrol     Publication Date:  1978  
Date Detail:
Created Date:  1978-12-20     Completed Date:  1978-12-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7513582     Medline TA:  Contrib Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
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MeSH Terms
Kidney / blood supply*
Krypton / diagnostic use*
Radioisotope Renography*
Radioisotopes / diagnostic use*
Regional Blood Flow
Rubidium / diagnostic use*
Reg. No./Substance:
0/Radioisotopes; 7439-90-9/Krypton; 7440-17-7/Rubidium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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