Document Detail

Unilateral hyperfusion in brain-perfusion SPECT predicts poor prognosis in acute encephalitis.
MedLine Citation:
PMID:  9153471     Owner:  NLM     Status:  MEDLINE    
We studied 88 patients with acute encephalitis using hexamethylpropyleneamine oxime and single photon emission computed tomography (SPECT). All patients had been initially treated with intravenous acyclovir. The etiology could be disclosed in 37 patients (42%), which included 15 patients with herpes simplex encephalitis, 7 with varicella-zoster encephalitis, and 29 with other encephalitides (Mycoplasma, adenovirus, influenza, rotavirus, rubella, Epstein-Barr, arbovirus, syphilis, and tuberculosis). Unilateral hyperperfusion in SPECT was an independent predictor of poor prognosis, whereas neither clinical outcome variables, such as seizures, state of consciousness, and focal neurologic findings, nor CSF or EEG findings were not. Focal unilateral hyperperfusion is an indicator of severe inflammation of the brain tissue and predicts a poor outcome as assessed in terms of activities of daily living after recovery.
J Launes; J Sirén; L Valanne; O Salonen; P Nikkinen; A M Seppäläinen; K Liewendahl
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  48     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-11     Completed Date:  1997-06-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1347-51     Citation Subset:  AIM; IM    
Department of Neurology, Helsinki University Central Hospital, Finland.
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MeSH Terms
Acute Disease
Brain / radionuclide imaging*
Cerebrovascular Circulation*
Encephalitis / diagnosis,  physiopathology*,  radionuclide imaging*
Magnetic Resonance Imaging
Middle Aged
Models, Theoretical
Regression Analysis
Tomography, Emission-Computed, Single-Photon*
Tomography, X-Ray Computed

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