Document Detail

Unilateral deep brain stimulation of the pedunculopontine tegmental nucleus in idiopathic Parkinson's disease: Effects on gait initiation and performance.
MedLine Citation:
PMID:  24908195     Owner:  NLM     Status:  Publisher    
The pedunculopontine tegmental nucleus (PPTg) is a component of the locomotor mesencephalic area. In recent years it has been considered a new surgical site for deep brain stimulation (DBS) in movement disorders. Here, using objective kinematic and spatio-temporal gait analysis, we report the impact of low frequency (40Hz) unilateral PPTg DBS in ten patients suffering from idiopathic Parkinson's disease with drug-resistant gait and axial disabilities. Patients were studied for gait initiation (GI) and steady-state level walking (LW) under residual drug therapy. In the LW study, a straight walking task was employed. Patients were compared with healthy age-matched controls. The analysis revealed that GI, cadence, stride length and left pelvic tilt range of motion (ROM) improved under stimulation. The duration of the S1 and S2 sub-phases of the anticipatory postural adjustment phase of GI was not affected by stimulation, however a significant improvement was observed in the S1 sub-phase in both the backward shift of centre of pressure and peak velocity. Speed during the swing phase, step width, stance duration, right pelvic tilt ROM phase, right and left hip flexion-extension ROM, and right and left knee ROM were not modified. Overall, the results show that unilateral PPTg DBS may affect GI and specific spatio-temporal and kinematic parameters during unconstrained walking on a straight trajectory, thus providing further support to the importance of the PPTg in the modulation of gait in neurodegenerative disorders.
P Mazzone; M Paoloni; M Mangone; V Santilli; A Insola; M Fini; E Scarnati
Related Documents :
1500975 - Local stimulation of proteoglycan synthesis in articular cartilage explants by dynamic ...
12897985 - Mechanical properties of the rotator cuff: response to cyclic loading at varying abduct...
10541745 - Kinematic synergies and equilibrium control during trunk movement under loaded and unlo...
20121065 - Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared ...
11540775 - Synthesis of ethological studies on behavioural adaptation of the astronaut to space fl...
10427925 - How to protect your eyes from solar retinopathy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-14
Journal Detail:
Title:  Gait & posture     Volume:  -     ISSN:  1879-2219     ISO Abbreviation:  Gait Posture     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-6-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9416830     Medline TA:  Gait Posture     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Treatment of prolonged convulsive seizures in children; a single centre, retrospective, observationa...
Next Document:  Age estimation in U-20 football players using 3.0 tesla MRI of the clavicle.