Document Detail

Unilateral continuous subclinical paroxysmal activity: an unusual finding in a patient with recurrent absence status.
MedLine Citation:
PMID:  21078584     Owner:  NLM     Status:  MEDLINE    
We report a patient with a history of rare generalised tonic-clonic seizures and recurrent absence status who was diagnosed with a rare variant of idiopathic generalised epilepsy and absence status epilepsy. No other pathology was identified and MRI was normal. During a follow-up of 17 years, we recorded a single unilateral continuous, strictly subclinical, paroxysmal activity which lasted for at least several hours. No control was observed under treatment with phenobarbital, lamotrigine and topiramate. Absence status was aggravated with carbamazepine and generalised tonic-clonic seizures were not controlled with ethosuximide. Total seizure control was only possible with sodium valproate, which caused weight gain, and the patient has remained seizure-free for the past 10 years under 1,000 mg/d valproate and 200 mg/d topiramate. The recorded unilateral, long-lasting, subclinical spike-and-wave discharge is quite unusual for idiopathic generalised epilepsy and, in our opinion, occupies a transitional position between generalised and focal activity.
Reana Velizarova; Pierre Genton
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-11-16
Journal Detail:
Title:  Epileptic disorders : international epilepsy journal with videotape     Volume:  12     ISSN:  1294-9361     ISO Abbreviation:  Epileptic Disord     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-24     Completed Date:  2011-03-08     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  100891853     Medline TA:  Epileptic Disord     Country:  France    
Other Details:
Languages:  eng     Pagination:  316-20     Citation Subset:  IM    
Centre Saint-Paul, Marseille, Hôpital Gui de Chauliac, Montpellier, France.
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MeSH Terms
Anticonvulsants / administration & dosage*,  adverse effects*
Brain / drug effects,  physiopathology*
Carbamazepine / administration & dosage,  adverse effects
Diagnosis, Differential
Dose-Response Relationship, Drug
Epilepsy, Tonic-Clonic / diagnosis,  drug therapy,  physiopathology*
Follow-Up Studies
Fructose / administration & dosage,  adverse effects,  analogs & derivatives
Phenobarbital / administration & dosage,  adverse effects
Recurrence / prevention & control
Status Epilepticus / diagnosis,  drug therapy,  physiopathology*
Treatment Outcome
Triazines / administration & dosage,  adverse effects
Valproic Acid / administration & dosage,  adverse effects
Weight Gain / drug effects
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; 0H73WJJ391/topiramate; 298-46-4/Carbamazepine; 30237-26-4/Fructose; 50-06-6/Phenobarbital; 99-66-1/Valproic Acid; U3H27498KS/lamotrigine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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