| Unilateral cervical vagotomy decreases the magnitude of neurogenic inflammation induced by capsaicin in the ipsilateral bronchial tree of rats. | |
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MedLine Citation:
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PMID: 8279699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electrical stimulation of a single cervical vagus nerve produces neurogenic inflammation on the stimulated side of the bronchial tree, including the first (main) to the 4th order bronchi. In the contralateral bronchial tree, in contrast, only the proximal part of the main bronchus exhibits inflammatory changes, suggesting that vagal sensory axons present in the bronchi largely originate from the ipsilateral vagus nerve. Intravenous administration of capsaicin can evoke neurogenic inflammation in bilateral bronchial trees. Sensory axons from various sources are thought to be stimulated by this irritant. The extent to which neurogenic inflammation in both bronchial trees might be reduced by unilateral vagotomy is not known. In the present study, we sought to characterize the effect of unilateral cervical vagotomy on capsaicin-induced changes in plasma extravasation and secretory activity of goblet cells in the bronchial trees of both sides. To quantify the magnitude of neurogenic plasma extravasation, Evans blue was used as a tracer dye to measure spectrophotometrically its amount in the bronchial wall. Another tracer dye, Monastral blue, was used to localize the distribution of leaky blood vessels and to measure morphometrically their area density in the whole mounts. To investigate cell and tissue responses of the mucosa, histological methods were employed. After 2 or 4 postoperative weeks, the rats were intravenously administered with a single dose of capsaicin, 150 micrograms/kg. This resulted in different magnitudes of Evans blue extravasation in the bronchi of the two sides in vagotomized rats. Extravasation of Evans blue dye in the bronchial tree ipsilateral to vagotomy was one-half to two-thirds of that of the contralateral bronchial tree.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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H T Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anatomy and embryology Volume: 188 ISSN: 0340-2061 ISO Abbreviation: Anat. Embryol. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-02-07 Completed Date: 1994-02-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7505194 Medline TA: Anat Embryol (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 363-70 Citation Subset: IM |
Affiliation:
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Department of Biology, National Sun Yat-Sen University, Kaohsiung, Taiwan, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchi / drug effects*, innervation*, pathology Bronchitis / chemically induced, pathology, prevention & control Capillary Permeability / drug effects Capsaicin / toxicity* Electric Stimulation Female Male Mucous Membrane / blood supply, drug effects, pathology Rats Rats, Sprague-Dawley Vagotomy Vagus Nerve / physiology* |
| Chemical | |
Reg. No./Substance:
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404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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