Document Detail


Unilateral auditory cortex ablation in macaques results in a contralateral hearing loss.
MedLine Citation:
PMID:  2769359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The behavioral audiograms of four Japanese macaques (Macaca fuscata) were assessed before and after unilateral ablation of auditory cortex. The tones were presented via insertion earphones so that each ear could be tested separately. 2. Each animal had a hearing loss in the ear contralateral to the lesion, whereas the ipsilateral ear showed no change in sensitivity. The hearing loss initially appeared as a large shift in thresholds followed by rapid but incomplete recovery during the first 3-5 wk after surgery. The initial hearing loss ranged as high as 68 dB at some frequencies, although thresholds at other frequencies were occasionally unchanged. A threshold shift could be demonstrated with broadband noise as well as with tones. Although thresholds for some tones returned to normal within a few weeks, most were still elevated 16 wk after surgery when testing was discontinued. The largest long-term hearing losses occurred at frequencies from 4 to 25 kHz. 3. Analysis of the animals' psychophysical functions suggested that the hearing loss resembled a sensory deficit, as opposed to a nonsensory deficit in attention or vigilance. 4. Testing with binaural stimuli indicated that the hearing loss could best be described as a contralateral "ear" deficit, as opposed to a contralateral "auditory field" deficit. 5. It is suggested that a similar hearing loss occurs in humans after unilateral damage to auditory cortex.
Authors:
H E Heffner; R S Heffner
Related Documents :
15565779 - Adaptive stochastic resonance in noisy neurons based on mutual information.
4051879 - Auditory brainstem evoked potentials in blast injury.
7184149 - Stereociliary pathology and noise-induced threshold shift: a scanning electron microsco...
9873149 - Frequency-specific threshold determination with the ceragram method: basic principle an...
9213119 - Effect of olivocochlear bundle section on evoked otoacoustic emissions recorded using m...
2324019 - Mutant golden hamsters with an abnormal outer hair cell stereociliary arrangement.
1375889 - Brain-stem auditory evoked potentials in adults with down's syndrome.
12000029 - Pavlovian conditioning of emotional responses to olfactory and contextual stimuli: a po...
7499489 - Increased activity of hypothalamic corticotropin-releasing hormone neurons in multiple ...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurophysiology     Volume:  62     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-03     Completed Date:  1989-10-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  789-801     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Toledo, Ohio 43606.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Auditory Cortex / physiopathology*
Auditory Threshold
Evoked Potentials, Auditory
Functional Laterality*
Hearing Loss, Central / physiopathology*
Hearing Loss, Sensorineural / physiopathology*
Macaca
Male
Noise
Grant Support
ID/Acronym/Agency:
HD-02528/HD/NICHD NIH HHS; NS-12992/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Responses of primate spinothalamic tract neurons to renal pelvic distension.
Next Document:  Functional anatomy of the second visual area (V2) in the macaque.