Document Detail

Unilateral adrenal tumor, erectile dysfunction and infertility in a patient with 21-hydroxylase deficiency: effects of glucocorticoid treatment and surgery.
MedLine Citation:
PMID:  12605349     Owner:  NLM     Status:  MEDLINE    
In untreated congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHDS) the presence of adrenal and testicular tumors had been described; however little is known about the effect of the enzymatic defect on fertility in males. We studied a male adult patient affected by 21OHDS for infertility, after a long period of discontinuation of glucocorticoid therapy and then during resumption of treatment and 8 months after monoadrenalectomy. The initial spermatic count revealed azoospermia and testicular needle aspiration showed a cytological picture consistent with prepuberty. The morphofunctional study revealed a right adrenal mass with reduced uptake at radioscan. Treatment was resumed with onset of impotency, which improved after reduction of the dose of glucocorticoids. The patient was monoadrenalectomised and his spermatic count increased. The patient shows that corticosteroid therapy in 21OHDS should be continued lifelong to avoid adrenal hyperplasia with possible areas of autonomy and to allow regular fertility. Impotence during treatment is probably due to a decrease of excessive adrenal androgens while testicular androgen production is still suppressed.
C Scaroni; G Favia; F Lumachi; G Opocher; G Bonanni; F Mantero; D Armanini
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association     Volume:  111     ISSN:  0947-7349     ISO Abbreviation:  Exp. Clin. Endocrinol. Diabetes     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-26     Completed Date:  2003-09-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9505926     Medline TA:  Exp Clin Endocrinol Diabetes     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  41-3     Citation Subset:  IM    
Department of Endocrinology, University of Padova, Padova, Italy.
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MeSH Terms
Adrenal Gland Neoplasms / complications,  radionuclide imaging,  surgery*
Adrenal Hyperplasia, Congenital / therapy*
Erectile Dysfunction / complications,  drug therapy*
Glucocorticoids / therapeutic use*
Infertility, Male / complications,  drug therapy*
Spermatic Cord / pathology
Steroid 21-Hydroxylase / physiology*
Tomography, X-Ray Computed
Reg. No./Substance:
0/Glucocorticoids; EC 21-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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