Document Detail

Unilateral preoperative chest wall irradiation in bilateral tissue expander breast reconstruction with acellular dermal matrix: a prospective outcomes analysis.
MedLine Citation:
PMID:  23385983     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Prior breast irradiation increases the rate of postoperative complications, including capsular contracture, in tissue expander/implant reconstruction. Acellular dermal matrix is heralded to decrease capsular contracture, but recent evidence suggests a possible increase in postoperative complications. The authors evaluated outcomes in patients undergoing bilateral tissue expander/implant reconstruction with acellular dermal matrix in the setting of prior unilateral irradiation.
METHODS: A case-control study was conducted on all patients undergoing bilateral, acellular dermal matrix-assisted, tissue expander/implant reconstruction with a history of previous unilateral irradiation at Memorial Sloan-Kettering Cancer Center. Complication rates were compared.
RESULTS: Twenty-three patients met inclusion criteria and had an average follow-up of 19 months (range, 4 to 60 months). The perioperative infection rate was 21.7 percent (n = 5) in irradiated breasts and 4.3 percent (n = 1) in control breasts (p = 0.079). Mastectomy skin flap necrosis, explantation, hematoma, and seroma rates were not significantly different between the groups. Sixty percent of patients had irradiated breast contracture that was one Baker grade greater than that in the nonirradiated breast. Body mass index greater than 25 and smoking history were significant independent risk factors for early postoperative complications in univariate analysis (p = 0.01).
CONCLUSIONS: Previous irradiation does not appear to increase the risk of early postoperative complications associated with acellular dermal matrix use in tissue expander/implant breast reconstruction. However, body mass index greater than 25 and smoking history are cause for caution. In addition, acellular dermal matrix does not appear to affect the degree of capsular contracture formation in the setting of prior irradiation.
Katie E Weichman; Yeliz Cemal; Claudia R Albornoz; Colleen M McCarthy; Andrea L Pusic; Babak J Mehrara; Joseph J Disa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  131     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-30     Completed Date:  2013-07-16     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  921-7     Citation Subset:  AIM; IM    
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MeSH Terms
Acellular Dermis*
Body Mass Index
Breast Neoplasms / epidemiology,  radiotherapy*,  surgery*
Case-Control Studies
Follow-Up Studies
Mastectomy, Segmental*
Middle Aged
Postoperative Complications / epidemiology,  pathology,  prevention & control
Prospective Studies
Radiation Injuries / epidemiology
Retrospective Studies
Risk Factors
Smoking / epidemiology
Surgical Flaps / pathology
Tissue Expansion Devices*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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